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Schematic diagram illustrating IGF2BP3 function. IGF2BP3 can decrease ZO-1 mRNA stability by enhancing miR191-5p expression and inducing the RISC-mRNA interaction. ZO-1, zonula occludens-1; IGF2BP3, insulin-like growth factor II mRNA-binding protein 3; RISC, RNA-induced silencing complex; miR, microRNA; RISC, RNA-induced silencing complex; UTR, untranslated region.
