Table 2. Nanoparticle Batches of PLGA 503H and PLGA 2300 Loaded with TMP Used for Adhesion Studiesa.
| batch | z-avg [nm] | PDI | TMP load [%] | surface-bound WGA [μg/mgparticles] |
|---|---|---|---|---|
| 503H no TMP | 215.3 ± 0.6 | 0.089 ± 0.01 | 7.480 ± 0.05 | |
| 503H 1.5% TMP | 240.2 ± 3.1 | 0.152 ± 0.01 | 1.52 ± 0.01 | 5.230 ± 0.23 |
| 503H 19.5% TMP | 191.9 ± 1.4 | 0.154 ± 0.02 | 19.48 ± 0.01 | 5.210 ± 0.06 |
| 2300 no TMP | 390.6 ± 4.1 | 0.208 ± 0.01 | 3.348 ± 0.05 | |
| 2300 4.3% TMP | 326.7 ± 2.9 | 0.180 ± 0.01 | 4.26 ± 0.19 | 3.906 ± 0.05 |
| 2300 7.5% TMP | 286.7 ± 1.1 | 0.173 ± 0.02 | 7.50 ± 0.55 | 3.805 ± 0.10 |
a
Particle modification had no effect on the size and TMP load. All measurements were carried out in triplicates. All pairwise comparison (Holm–Sidak method) resulted in statistical significant differences (p ≤ 0.001) for the size, TMP load, and WGA on the surface for all batches except for WGA on the surface of 2300 4.3% TMP and 2300 7.5% TMP, which showed no significant differences (p ≥ 0.05).