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. 2020 May 21;20(2):1179–1192. doi: 10.3892/ol.2020.11664

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Copyright: © Dongol et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — IQGAP3 expression is upregulated in HGSOC and its increased expression is associated with a poorer prognosis. (A) Survival analysis based on immunohistochemical analysis identified significantly improved overall survival (log rank P=0.0149) and progression-free survival (log rank P=0.0044) in patients with lower expression levels of IQGAP3. (B) Kaplan-Meier survival plots based on data obtained from the Gene Expression Omnibus database had improved overall and progression-free survival in cases with lower expression levels of IQGAP3. (C) Western blotting results demonstrated higher protein expression levels of IQGAP3 in HGSOC tissues (T1-T5) compared with healthy FTE (F1-F3). Expression of IQGAP3 between the two groups was significantly different. (D) Reverse transcription-quantitative-PCR analysis indicated higher mRNA expression levels of IQGAP3 in HGSOC tissues (n=26) compared with FTE (n=24). (E) Immunohistochemical staining of IQGAP3 in HGSOC and FTE samples. Magnification, ×40. *P<0.05; **P<0.01; ***P<0.001. IQGAP3, IQ motif containing GTPase Activating Protein 3; HGSOC, high-grade serous ovarian cancer; FTE, fallopian tube epithelium.