Table I.
Association of caprin-1 protein and mRNA expression levels with clinicopathological characteristics in patients with liver cancer.
| Tissue microarray | The Cancer Genome Atlas database | ||||||
|---|---|---|---|---|---|---|---|
| Clinical features | Number | Low, n (%) | High, n (%) | P-value | Number | Mean ± SD | P-value |
| Cancer | 39 | 7 (17.9) | 32 (82.1) | <0.001a | 134 | 3,516.17±1,370.19 | – |
| Benign | 30 | 24 (80.0) | 6 (20.0) | – | – | – | |
| Age, years | |||||||
| <45 | 15 | 2 (13.3) | 13 (86.7) | 0.444 | 67 (<65) | 3,300.31±1,319.87 | 0.034b |
| ≤45 | 24 | 5 (20.8) | 19 (79.2) | 67 (≥65) | 3,784.58±1,299.38 | ||
| Sex | |||||||
| Male | 8 | 1 (12.5) | 7 (87.5) | 0.554 | 80 | 3,407.94±1,228.09 | 0.154 |
| Female | 31 | 6 (19.4) | 25 (80.6) | 54 | 3,741.71±1,450.62 | ||
| Pathological grade | |||||||
| ≤2 | 29 | 3 (10.3) | 26 (89.7) | 0.131 | – | – | – |
| >2 | 9 | 3 (33.3) | 6 (66.7) | – | – | – | – |
| Clinical stage | |||||||
| I–II | 15 | 7 (46.7) | 8 (53.3) | <0.001a | – | – | – |
| III–IV | 24 | 0 (0.0) | 24 (100.0) | – | – | – | |
| Tumor invasion | |||||||
| T1-T2 | 15 | 7 (46.7) | 8 (53.3) | <0.001a | 86 | 3,473.89±1,067.72 | 0.044b |
| T3-T4 | 24 | 0 (0.0) | 24 (100.0) | 48 | 3,865.27±1,079.35 | ||
| Lymph node metastasisc | |||||||
| N0 | – | – | – | – | 83 | 3,649.43±1,407.77 | 0.902 |
| N1 | – | – | – | – | 3 | 3,751.22±1,195.26 | |
| Distant metastasisd | |||||||
| M0 | – | – | – | – | 99 | 3,593.43±1,401.42 | 0.534 |
| M1 | – | – | – | – | 3 | 3,084.15±725.15 | |
a
P<0.001
b
P<0.05.
c
In total, 48 patients had no information of lymph node metastasis.
d
In total, 32 patients had no information regarding distant metastasis. Low, <mean caprin-1 protein expression level; High, >mean caprin-1 protein expression level.