Table II.

Prognostic value of caprin-1 mRNA expression levels for overall survival based on Cox proportional hazards model.

A, Univariate analysis
	Overall survival
Variable	HR (95%CI)	P-value
Tumor status, tumor vs. tumor free	1.826 (1.060–3.146)	0.030a
Age, ≥65 vs. <65 years	0.768 (0.463–1.276)	0.309
Sex, male vs. female	1.312 (0.782–2.201)	0.304
Clinical stage, I–II vs. III–IV	1.120 (0.646–1.943)	0.686
Tumor invasion, T1-T2 vs. T3-T4	2.701 (1.203–6.061)	0.016a
Lymph node stage, N0 vs. N1	0.676 (0.091–5.005)	0.676
Distant metastasis, M0 vs. M1	2.917 (0.879–9.674)	0.080
Caprin-1 expression, low vs. high	2.284 (1.328–3.930)	0.003b
B, Multivariate analysis
	Overall survival
Variable	HR (95%CI)	P-value
Personal neoplasm status, with tumor vs. tumor free	3.573 (1.421–8.938)	0.007b
Age, ≥65 vs. <65 years	2.208 (0.934–5.218)	0.071
Sex, male vs. female	3.647 (1.493–8.909)	0.005b
Clinical stage, I–II vs. III–IV	0.877 (0.369–2.084)	0.766
Tumor invasion, T1-T2 vs. T3-T4	52.503 (6.706–411.079)	<0.001c
Lymph node stage, N0 vs. N1	0.407 (0.046–3.646)	0.422
Distant metastasis, M0 vs. M1	0.048 (0.004–0.574)	0.048a
Caprin-1 expression, low vs. high	7.299 (2.614–20.379)	<0.001c

^aP<0.05

^bP<0.01

^cP<0.001. HR, hazard ratio; CI, confidence interval; Low, <mean caprin-1 protein expression level; High, >mean caprin-1 protein expression level.