Figure 4.

(A) Toxic ratio TR, (B) specificity ratio ${\text{SR}}_{\text{cytotoxicity}}$, and (C) specificity ratio ${\text{SR}}_{\text{baseline}}$ of chemicals that triggered the specific effect (${\text{EC}}_{10}$) and/or were cytotoxic (${\text{IC}}_{10}$) within the measured concentration range in the six Tox21 reporter gene assays. The underlying data are in the Tables S1–S6. The total number of chemicals included in the analysis is given in the top row [number of chemicals n for which a TR could be derived n (TR); number of chemicals n for which an ${\text{SR}}_{\text{cytotoxicity}}$ could be derived n (${\text{SR}}_{\text{cytotoxicity}}$); number of chemicals n for which an ${\text{SR}}_{\text{baseline}}$ could be derived $n$ (${\text{SR}}_{\text{baseline}}$)]. The percentages in the top refer to all data with $\text{TR}/\text{SR}>10$ (diamond symbols); the percentages in the bottom refer to all data with $\text{TR}/\text{SR}\le 10$ (circle symbols).