Table 2.

Toxic ratio TR analysis for the six Tox21 in vitro reporter gene assays.

Reporter gene assay	$n$ (chemicals)a	$n$ (TR)b	$n\left(\text{TR}>10\right)$c		$n\left(1\le \text{TR}\le 10\right)$c		$n\left(\text{TR}<1\right)$c
ARE-BLA	7,214	694	384	(55.3%)	275	(39.6%)	35	(5.0%)
AhR-CALUX	7,968	930	524	(56.3%)	353	(38.0%)	52	(5.6%)
$\text{PPAR}\mathrm{\gamma }\text{-BLA}$	6,968	723	326	(45.1%)	349	(48.3%)	48	(6.6%)
AR-BLA	7,959	1,172	485	(41.4%)	532	(45.4%)	155	(13.2%)
$\text{ER}\mathrm{\alpha }\text{-BLA}$	7,947	610	193	(31.6%)	266	(43.6%)	151	(24.8%)
GR-BLA	7,963	599	204	(34.1%)	277	(46.2%)	118	(19.7%)

Note: The underlying data is given in Tables S1–S6.

^aNumber ($n$) of the evaluated chemicals [$n$ (chemicals)].

^bNumber of chemicals $n$ for which a TR could be derived $n$ (TR).

^cBinning into the TR categories ($\text{TR}>10$, $1\le \text{TR}\le 10$, $\text{TR}<1$). In parentheses are the percentages of categories in each bin.