Table 3.

Specificity ratio ${\text{SR}}_{\text{cytotoxicity}}$ analysis for the six Tox21 in vitro reporter gene assays.

Reporter gene assay	$n$ (chemicals)a	$n$ (${\text{SR}}_{\text{cytotoxicity}}$)b	$n$ (${\text{SR}}_{\text{cytotoxicity}}>10$)c		$n$ ($1\le {\text{SR}}_{\text{cytotoxicity}}\le 10$)c		$n$ (${\text{SR}}_{\text{cytotoxicity}}<1$)c
ARE-BLA	7,214	332	29	(8.7%)	180	(54.2%)	123	(37.0%)
AhR-CALUX	7,968	305	29	(9.5%)	115	(37.7%)	161	(52.8%)
$\text{PPAR}\mathrm{\gamma }\text{-BLA}$	6,968	75	2	(2.7%)	12	(16.0%)	61	(81.3%)
AR-BLA	7,959	204	29	(14.2%)	42	(20.6%)	133	(65.2%)
$\text{ER}\mathrm{\alpha }\text{-BLA}$	7,947	181	13	(7.2%)	46	(25.4%)	122	(67.4%)
GR-BLA	7,963	121	2	(1.7%)	14	(11.6%)	105	(86.8%)

Note: The underlying data is given in Tables S1–S6.

^aNumber ($n$) of the evaluated chemicals [$n$ (chemicals)].

^bNumber of chemicals $n$ for which a ${\text{SR}}_{\text{cytotoxicity}}$ could be derived $n$ (${\text{SR}}_{\text{cytotoxicity}}$).

^cBinning into the ${\text{SR}}_{\text{cytotoxicity}}$ categories (${\text{SR}}_{\text{cytotoxicity}}>10$, $1\le {\text{SR}}_{\text{cytotoxicity}}\le 10$, ${\text{SR}}_{\text{cytotoxicity}}<1$). In parentheses are the percentages of categories in each bin.