Table 4.

Specificity ratio ${\text{SR}}_{\text{baseline}}$ analysis for the six Tox21 in vitro reporter gene assays.

Reporter gene assay	$n$ (chemicals)c	$n$ (${\text{SR}}_{\text{baseline}}$)b	$n$ (${\text{SR}}_{\text{baseline}}>10$)c		$n$ ($1\le {\text{SR}}_{\text{baseline}}\le 10$)c			$n$ (${\text{SR}}_{\text{baseline}}<1$)c
ARE-BLA	7,214	1,077	700	(65.0%)	341	(31.7%)	36		(3.3%)
AhR-CALUX	7,968	837	495	(59.1%)	270	(32.3%)	72		(8.6%)
$\text{PPAR}\mathrm{\gamma }\text{-BLA}$	6,968	145	86	(59.3%)	45	(31.0%)	14		(9.7%)
AR-BLA	7,959	318	186	(58.5%)	94	(29.6%)	38		(11.9%)
$\text{ER}\mathrm{\alpha }\text{-BLA}$	7,947	307	114	(37.1%)	117	(38.1%)	76		(24.8%)
GR-BLA	7,963	187	106	(56.7%)	43	(23.0%)	38		(20.3%)

Note: The underlying data is given in Tables S1–S6.

^aNumber ($n$) of the evaluated chemicals [$n$ (chemicals)].

^bNumber of chemicals ($n$) for which a ${\text{SR}}_{\text{baseline}}$ could be derived $n$ (${\text{SR}}_{\text{baseline}}$).

^cBinning into the ${\text{SR}}_{\text{baseline}}$ categories (${\text{SR}}_{\text{baseline}}>10$, $1\le {\text{SR}}_{\text{baseline}}\le 10;{\text{SR}}_{\text{baseline}}<1$). In parentheses are the percentages of categories in each bin.