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. 2020 Jul 23;128(7):077008. doi: 10.1289/EHP7030

Figure 1.

Figure 1 is a schematic diagram of Polychlorinated biphenyls and their metabolites, including three lower chlorinated P C Bs, namely, P C B 3, P C B 11, and P C B 52 and a selection of hydroxylated, di-hydroxylated, methoxylated, and sulfated metabolites, namely, P C B 95, P C B 126, plus or minus P C B 136, P C B 153, 2-P C B 3 sulfate, and 3-P C B 3 sulfate. P C B 3 is connected to 2 prime-O H-P C B 3, 3 prime-O H-P C B 3, and 4 prime-O H-P C B 3 with forward arrow. 2 prime-O H-P C B 3 is connected to 2 prime, 5 prime-d i O H-P C B 3 with a bidirectional arrow, which is connected to 4-C I-B Q with a bidirectional arrow; 3 prime-O H-P C B 3 is connected to 3 prime-P C B 3 sulfate with a bidirectional arrow; and 4 prime-O H-P C B 3 is connected to 4 prime P C B 3 sulfate and 4 prime-M e O-P C B 3, each with a bidirectional arrow. P C B 11 is connected to 4-O H-P C B 11 with a forward arrow, which is connected to 4-P C B 11 sulfate and 4-M e O-P C B 11, each with a bidirectional arrow. P C B 52 is connected to 4-O H-P C B 52 with a forward arrow, which is connected to 4-P C B 52 sulfate and 4-M e O-P C B 52, each with a bidirectional arrow.

PCBs and their metabolites selected for in vitro cardiovascular toxicity testing. The library included three lower chlorinated PCBs (3, 11, and 52) and a selection of hydroxylated, di-hydroxylated, methoxylated, and sulfated metabolites. The higher-chlorinated (≥5 chlorine atoms) PCBs 95, 126, 153, and the atropisomers (+)- and (−)-PCB 136 were also included. Chemical names and abbreviations of PCBs and metabolites are listed in Table S1. Note: PCB, polychlorinated biphenyls.