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. 2020 Jul 23;128(7):077008. doi: 10.1289/EHP7030

Figure 2.

Figure 2A is a display of C a squared positive flux traces for media and D M S O (0.5 percent) under R F U. It displays effects of polychlorinated biphenyl metabolites, namely, 4-M e O-P C B 3, 5-O H-P C B 11, and 4-O H-P C B 52 in three columns, namely, 0.01 microMolar, 1 microMolar, and 100 microMolar, each showing results for 30 seconds in increments of 10. Figure 2B is a display of tubular networks for media and D M S O (0.5 percent). It displays effects of polychlorinated biphenyl metabolites, namely, 4 prime-M e O-P C B 3, 5-O H-P C B 11, and 4-O H-P C B 52 in three columns, namely, 0.01 microMolar, 1 microMolar, and 100 microMolar.

Effects of PCB metabolites on iCell®-cardiomyocytes and iCell®-endothelial cell. (A) Representative Ca2+ flux traces (90 min after treatment) for media, vehicle (0.5% DMSO) or three PCB metabolites at three concentrations on iPSC-derived CMs. (B) Representative images of the tubular networks for media, vehicle (0.5% DMSO), or three representative PCB metabolites at three concentrations on iPSC-derived ECs. Images were acquired at 4× resolution. Chemical names and abbreviations of PCBs and metabolites are listed in Table S1. Note: CMs, cardiomyocytes; DMSO, dimethyl sulfoxide; ECs, endothelial cells; iPSC, induced pluripotent stem cell; PCBs, polychlorinated biphenyls.