Figure 1.

Pharmacokinetics of VRC01 after a single subcutaneous dose administered within 72 hours of birth. Plasma concentrations of VRC01 (micrograms [mcg]/mL) determined as described in Methods at study visit days 1, 3, 7, 14, 28, 56, 112, and 168 (Dose Group 2 only) for Dose Group 1 (20 mg/kg) in red and for Dose Group 2 (40 mg/kg) in blue. Dose Group 3 (purple bars) received a single dose of 40 mg/kg within 5 days of birth, followed by monthly doses of 20 mg/kg. Levels from day 28 on represent trough levels. Solid black line indicates targeted trough of 50 mcg/mL. Error bars indicate standard deviation