Figure 5.

Plasma concentrations of inflammatory biomarkers can distinguish Zika virus (ZIKV) infection with or without microcephaly (MC) from uninfected controls. (A) In an exploratory approach, a sparse canonical correlation analysis (sCCA) was used to test whether experimental groups could be distinguished based on the overall expression profile of all the markers measured. (B) Canonical coefficient scores were calculated to identify the biomarkers responsible for the difference between groups in the sCCA model. HC, healthy control.