Table 4.
Sensitivity Analyses for the Modification of the Effect of Smoking on Oral HPV (α-High Risk, HPV 16, and β-1 Species) by HIV
| HPV | Smoking | Past Smoker on Oral HPV Within Strata of HIV | Current Smoker on Oral HPV Within Strata of HIV | ||
|---|---|---|---|---|---|
| Never | Past | Current | |||
| α-High-risk HPVa | |||||
| HIV negative, OR | 1.0 | 1.52 (.24–9.69) | 1.53 (.32–8.53) | 1.52 (.24–9.69) | 1.53 (.32–8.53) |
| HIV positive, OR | 1.58 (.32–8.72) | 4.33 (1.05–22.84) | 6.24 (1.72–30.76) | 3.33 (.85–13.10) | 3.55 (.98–12.80) |
| RERI | … | 2.23 (−2.53 to 6.99) P = .17 | 4.12 (−2.03 to 10.28) P = .09 | … | … |
| AP | … | 0.51 (−.25 to 1.28) P = .09 | 0.66 (.19–1.13) P = .002 | … | … |
| α-HPV 16 | |||||
| HIV negative, OR | 1.0 | 1.45 (.15–14.19) | 1.69 (.24–14.70) | 1.45 (.15–14.19) | 1.69 (.24–14.70) |
| HIV positive, OR | 1.76 (.26–14.53) | 3.29 (.55–27.48) | 4.85 (.96–38.10) | 2.12 (.40–11.30) | 2.54 (.53–12.14) |
| RERI | … | 1.08 (−3.73 to 5.90) P = .33 | 2.41 (−3.26 to 8.07) P = .20 | … | … |
| AP | … | 0.33 (−.94 to 1.60) P = .31 | 0.50 (−.30 to 1.29) P = .11 | … | … |
| β-1b | |||||
| HIV negative, OR | 1.0 | 1.21 (.43–3.47) | 1.06 (.42–2.69) | 1.21 (.43–3.47) | 1.06 (.42–2.69) |
| HIV positive, OR | 1.70 (.67–4.38) | 3.85 (1.47–10.55) | 5.03 (2.11–12.53) | 2.29 (.86–6.15) | 2.93 (1.20–7.14) |
| RERI | … | 1.95 (−1.44 to 5.34) P = .13 | 3.27 (−.24 to 6.78) P = .03 | … | … |
| AP | … | 0.51 (−.11 to 1.12) P = .05 | 0.65 (.30–1.00) P = .0001 | … | … |
ORs adjusted for age, sex, race, oral sex history, and lifetime number of sexual partners. Values in parentheses are 95% confidence intervals.
Abbreviations: AP, attributable proportion; HIV, human immunodeficiency virus; HPV, human papillomavirus; OR, odds ratio; RERI, relative excess risk due to interaction.
aHPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59.
bIncludes HPV 5 and 8.