Table 5.
Comparison of patients with an increase in driving pressure with those with a decrease in driving pressure 24 h after initiation of ECMO
| Increase in driving pressure | Decrease in driving pressure | P value | |
|---|---|---|---|
| Group A | Group B | ||
| Number | 32 (49%) | 33 (51%) | |
| Male sex | 23 (72%) | 21 (64%) | 0.478 |
| Body mass index (Kg/m2) | 33 ± 11 | 29 ± 9.7 | 0.099 |
| Acute respiratory distress syndrome | 19 (59%) | 13 (39%) | 0.107 |
| Veno-venous ECMO | 20 (62%) | 9 (27%) | 0.004 |
| Ventilator parameters | |||
| PEEP before cannulation (cm H2O) | 14 ± 5 | 9 ± 4 | < 0.001 |
| PEEP 24 h after ECMO (cm H2O) | 7 ± 2 | 7 ± 2 | 0.262 |
| Change in PEEP (cm H2O) | − 6.4 ± 5 | − 2.5 ± 3 | < 0.001 |
| Compliance prior cannulation (mL/cm H2O) | 29 ± 11 | 31 ± 19 | 0.580 |
| Compliance 24 h after ECMO (mL/cm H2O) | 23 ± 9 | 32 ± 14 | 0.002 |
| Change in compliance (mL/cm H2O) | − 7.8 ± 11 | 0.5 ± 10 | 0.012 |
| ECMO circuit | |||
| Sweep gas flow after cannulation (L/min) | 5.2 ± 2 | 4.3 ± 1.9 | 0.090 |
| ECMO flow after cannulation (L/min) | 4.6 ± 0.8 | 4.5 ± 0.9 | 0.863 |
| Respiratory rate after cannulation | 11 ± 2 | 11 ± 3 | 0.472 |
| Temperature after cannulation (degree Fahrenheit) | 97.6 ± 2.6 | 98.1 ± 1.2 | 0.321 |
| Outcomes | |||
| Days on ECMO (days) | 13 ± 8 | 9 ± 5 | 0.022 |
| Length of stay after ECMO (days) | 30 ± 19 | 37 ± 37 | 0.528 |
| Died on ECMO | 10 (31%) | 10 (30%) | 0.958 |
| 30-day mortality | 13 (42%) | 11 (34%) | 0.537 |
| Discharge disposition | |||
| Home | 2 (6.4) | 3 (9.4) | |
| Long-term acute care facility | 2 (6.4) | 3 (9.4) | |
| Rehabilitation facility | 13 (42) | 11 (34.4) | |
Data are presented mean ± std. or number (percentage)
PEEP positive end expiratory pressure; ECMO extracorporeal membrane oxygenation