. Author manuscript; available in PMC: 2020 Jul 23.

Published in final edited form as: Prog Mol Biol Transl Sci. 2016 Mar 23;140:1–45. doi: 10.1016/bs.pmbts.2015.12.003

Table 1.

List of Chromosome Locations and Obesity Genes in Relationship to Obesity Phenotypes.

Genetic Factors and Relationship to Obesity Phenotypes	Chromosome Location and Candidate Gene for Obesity
Obesity, early onset	1p36.11 (NROB2); 2p23.3 (POMC); 18q21.32 (MC4R)
Obesity, severe	3p25.2 (PPARG); 6q16.3 (SIM1); 11q13.4 (ULP3); 16p11.2 (SH2B1)
Obesity, generalized	1p35.2 (SDC3); 3p25.3 (GHRL); 4q31.1 (UCP1); 5q13.2 (CART); 5q32 (ADRB2; PPARGC1B); 6q23.2 (ENPP1); 8p11.23 (ADRB3); 11p14.1 (BDNF); 13q14 (OLFM4); 14q32.2 (MEG-DMR); 16p11.2 (SH2B1); 16q12.2 (FTO); 16q22.1 (AGRP); 17q21 (HOXB5); 17q21.31 (PYY); 18q21.32 (MC4R)
Description	Gene of Interest

Genetic loci associated with child and/or adult BMI levels including extreme obesity identified by genome-wide studies (GWAS), linkage or with CNV/SNP microarrays	FTO; TMEM18; GNPDA2; INSIG2; MC4R; NEGR1; BDNF; KCTD15; PCSK1; CTNNBL1; MTCH2; NPC1; MAF; PTER; PRL; FAIM2; TFAP2B; SEC16B; ETV5; AIF1; GPRC5BB; MAP2K5; GIPR; FANCL; SDCCAG8; TNKS-MSRA; TNN13K; LRRN6C; NRXN3; FLJ35779; SLC39A8; TMEM160; CADM2; LRP1B; PRKD1; MTIF3; ZNF608; PTBP2; TUB; HMGA1; PPYR1
Associated with childhood obesity—novel loci	SH2B1; EDIL3; S1PR5; FOXP2; TBCA; ABCB5; ZPLD1; KIF2B; ARL15; EPHA6-UNQ6114
Associated with childhood and/or adult waist to hip ratio	LYPLAL1; C12orf51; LY86; HOXC13; RSPO3; VEGFA; TBX15; NFE2L3; GRB14; DNM3; PIGC; ITPR2; ADAMTS9; ZNRF3; NISCH; CPEB4