Fig 7. Vasoconstrictor and arterial wall [Ca2+]i responses to ET-1 are attenuated in response to ASIC1a inhibition and augmented in response to Orai1 inhibition in pulmonary arteries.
Vasoconstriction (percent baseline inner diameter; top panels) and changes in fura-2 ratio (F340/F380; bottom panels) in response to endothelin-1 (ET-1; 10−11–10−7 or 10−11–10−8) in the presence or absence of PcTX1 (20 nM) or AnCoA4 (20 μM) in small pulmonary (A) and mesenteric (B) arteries. N = 4–7 per group, values are means ± SEM. *p ≤ 0.05 vs. vehicle; ** p < 0.01, *** p ≤ 0.001, **** p ≤ 0.0001; analyzed by two-way anova followed by Dunnett’s multiple comparisons test.