. 2020 Jul 23;15(7):e0236505. doi: 10.1371/journal.pone.0236505

Table 4. Antibacterial action of CCeo and trans-cinnamaldehyde using disk-diffusion and broth microdilution and synergism between CCeo and antibiotics using disk-diffusion as screening.

Method	Antimicrobial agent	Bacteria
Method	Antimicrobial agent	KP-KPC	SM-KPC
MIC	CCeo	25 mm (S)	16 mm (S)
MIC	TC	281.25 μg.mL^-1	281.25 μg.mL^-1
Disk-diffusion	CCeo	281.25 μg.mL^-1	281.25 μg.mL^-1
	IPM	0 mm	0 mm
	CCeo + IPM	25 mm ^*	20 mm ^*
	POL	20 mm	14 mm
	CCeo + POL	2 mm ^*	6 mm ^*

CCeo: Cinnamomum cassia essential oil; IPM: imipenem; IR: intrinsic resistance; KP-KPC: carbapenemase-producing K. pneumoniae; MIC: minimum inhibitory concentration; POL: polymyxin B; S: susceptibility; SM-KPC: carbapenemase-producing S. marcescens; TC: trans-cinnamaldehyde

*: diameter of inhibition zone in mm of CCeo + antibiotic minus diameter of inhibition zone of antibiotic.