Table 4. Univariable Fine-Gray regression models assessing demographic, social, and clinical predictors of risk of EC death in Florida, 2005–2016.
| Prognostic Factors/Category | All cases (4,100 EC and 1,969 other cause deaths, 21,020 alive) | Type 1 EC cases (1,043 EC and 1,204 other cause deaths, 14,372 alive) | Type 2 EC cases (3,057 EC and 765 other cause deaths, 6,648 alive) | |||
|---|---|---|---|---|---|---|
| sHR (95%CI) | P | sHR (95%CI) | P | sHR (95%CI) | P | |
| Age | ||||||
| 14–44 | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| 45–54 | 1.07 (0.86, 1.33) | 0.569 | 0.94 (0.64, 1.39) | 0.768 | 0.97 (0.74, 1.27) | 0.813 |
| 55–64 | 1.88 (1.54, 2.28) | < .0001 | 1.70 (1.22, 2.38) | 0.002 | 1.54 (1.21, 1.96) | 0.0005 |
| 65–74 | 2.65 (2.18, 3.21) | < .0001 | 2.27 (1.62, 3.18) | < .0001 | 1.88 (1.48, 2.39) | < .0001 |
| 75+ | 4.19 (3.45, 5.09) | < .0001 | 4.07 (2.90, 5.71) | < .0001 | 2.58 (2.03, 3.29) | < .0001 |
| Race/Ethnicity | ||||||
| Whites | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| Blacks | 2.09 (1.94, 2.26) | < .0001 | 1.27 (1.03, 1.55) | 0.022 | 1.59 (1.46, 1.73) | < .0001 |
| Hispanics | 0.89 (0.82, 0.97) | 0.012 | 0.77 (0.65, 0.92) | 0.004 | 0.88 (0.80, 0.98) | 0.017 |
| Asians | 0.93 (0.69, 1.25) | 0.636 | 0.23 (0.07, 0.71) | 0.011 | 1.05 (0.77, 1.42) | 0.777 |
| Insurance | ||||||
| Private | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| Medicare | 1.77 (1.65, 1.90) | < .0001 | 2.01 (1.74, 2.31) | < .0001 | 1.41 (1.30, 1.52) | < .0001 |
| Medicaid | 2.09 (1.88, 2.32) | < .0001 | 2.34 (1.90, 2.89) | < .0001 | 1.63 (1.45, 1.84) | < .0001 |
| No Insurance | 1.53 (1.33, 1.76) | < .0001 | 1.88 (1.44, 2.46) | < .0001 | 1.18 (1.00, 1.40) | 0.048 |
| Unknown | 1.47 (1.30, 1.67) | < .0001 | 1.70 (1.34, 2.16) | < .0001 | 1.30 (1.12, 1.51) | 0.0004 |
| Census Tract Poverty | ||||||
| 0%—<5% poverty | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| 5%—<10% poverty | 0.97 (0.88, 1.08) | 0.618 | 1.03 (0.84, 1.27) | 0.782 | 1.01 (0.89, 1.14) | 0.894 |
| 10%—<20% poverty | 1.10 (1.00, 1.22) | 0.059 | 1.16 (0.95, 1.42) | 0.135 | 1.09 (0.98, 1.23) | 0.124 |
| 20% - 100% poverty | 1.30 (1.17, 1.44) | < .0001 | 1.24 (1.00, 1.54) | 0.051 | 1.20 (1.06, 1.35) | 0.003 |
| Unknown or not applicable | 0.90 (0.66, 1.24) | 0.531 | 1.00 (0.55, 1.81) | 0.994 | 0.91 (0.62, 1.33) | 0.617 |
| SEER stage | ||||||
| Localized | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| Regional | 4.88 (4.51, 5.28) | < .0001 | 3.99 (3.48, 4.59) | < .0001 | 3.37 (3.06, 3.71) | < .0001 |
| Distant | 23.17 (21.25, 25.27 | < .0001 | 26.97 (22.17, 32.81 | < .0001 | 10.92 (9.85, 12.10) | < .0001 |
| Unknown | 5.90 (5.18, 6.72) | < .0001 | 6.47 (5.09, 8.22) | < .0001 | 3.40 (2.91, 3.98) | < .0001 |
| Type/Histology | ||||||
| Type 1, Low-Grade Endometrioid | 1 (Reference) | NA | NA | |||
| Type 2, All-combined | 5.95 (5.55, 6.37) | < .0001 | ||||
| (Detailed Subtype) | ||||||
| High-Grade Endometrioid | 4.59 (4.23, 4.97) | < .0001 | NA | 1 (Reference) | 0.358 | |
| Clear Cell | 5.72 (4.73, 6.92) | < .0001 | 1.24 (1.03, 1.50) | 0.022 | ||
| Carcinosarcoma | 12.60 (11.41, 13.92 | < .0001 | 2.72 (2.47, 2.98) | < .0001 | ||
| Mixed high-grade | 4.19 (3.65, 4.82) | < .0001 | 0.91 (0.79, 1.04) | 0.160 | ||
| Serous | 8.22 (7.44, 9.07) | < .0001 | 1.76 (1.60, 1.93) | < .0001 |
sHR: subdistribution hazard ratio. HR: hazard ratio. 95%CI: 95% confidence interval. P: two-sided p-value. NA: not applicable.