Table 5. Multivariable Fine-Gray regression models assessing demographic, social, and clinical predictors of risk of EC death in Florida, 2005–2016.
| Prognostic Factors/Category | Model 1 All cases (4,100 EC and 1,969 other cause deaths, 21,020 alive) | Model 2 Type 1 EC cases (1,043 EC and 1,204 other cause deaths, 14,372 alive) | Model 3 Type 2 EC cases (3,057 EC and 765 other cause deaths, 6,648 alive) | |||
|---|---|---|---|---|---|---|
| sHR (95%CI) | P | sHR (95%CI) | P | sHR (95%CI) | P | |
| Age | ||||||
| 14–44 | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| 45–54 | 0.99 (0.80, 1.24) | 0.986 | 0.99 (0.67, 1.46) | 0.954 | 0.98 (0.75, 1.29) | 0.983 |
| 55–64 | 1.59 (1.30, 1.93) | < .0001 | 1.78 (1.27, 2.50) | 0.001 | 1.47 (1.15, 1.87) | 0.002 |
| 65–74 | 1.93 (1.58, 2.35) | < .0001 | 2.41 (1.70, 3.42) | < .0001 | 1.72 (1.35, 2.20) | < .0001 |
| 75+ | 2.64 (2.15, 3.24) | < .0001 | 3.78 (2.63, 5.42) | < .0001 | 2.27 (1.77, 2.92) | < .0001 |
| Race/Ethnicity | ||||||
| Whites | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| Blacks | 1.21 (1.10, 1.33) | < .0001 | 1.18 (0.94, 1.48) | 0.147 | 1.23 (1.12, 1.36) | < .0001 |
| Hispanics | 0.80 (0.72, 0.89) | < .0001 | 0.75 (0.62, 0.90) | 0.002 | 0.83 (0.74, 0.94) | 0.002 |
| Asians | 0.81 (0.59, 1.10) | 0.125 | 0.20 (0.06, 0.65) | 0.007 | 1.00 (0.72, 1.38) | 0.976 |
| Insurance | ||||||
| Private | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| Medicare | 1.13 (1.03, 1.23) | 0.006 | 1.20 (1.01, 1.43) | 0.035 | 1.08 (0.98, 1.20) | 0.105 |
| Medicaid | 1.36 (1.21, 1.54) | < .0001 | 1.68 (1.33, 2.12) | < .0001 | 1.24 (1.08, 1.42) | 0.002 |
| No Insurance | 1.24 (1.05, 1.45) | 0.006 | 1.75 (1.31, 2.35) | 0.0002 | 1.07 (0.89, 1.29) | 0.444 |
| Unknown | 1.33 (1.16, 1.51) | < .0001 | 1.55 (1.23, 1.96) | 0.0002 | 1.25 (1.07, 1.45) | 0.005 |
| SEER stage | ||||||
| Localized | 1 (Reference) | 1 (Reference) | 1 (Reference) | |||
| Regional | 3.54 (3.26, 3.84) | < .0001 | 3.96 (3.44, 4.55) | < .0001 | 3.15 (2.86, 3.48) | < .0001 |
| Distant | 12.04 (10.89, 13.31) | < .0001 | 24.37 (19.85, 29.91) | < .0001 | 9.78 (8.78, 10.90) | < .0001 |
| Unknown | 3.74 (3.26, 4.30) | < .0001 | 5.62 (4.42, 7.13) | < .0001 | 3.07 (2.61, 3.60) | < .0001 |
| Type/Histology | ||||||
| Type 1, Low-Grade Endometrioid | 1 (Reference) | NA | NA | |||
| Type 2, All-combined | 2.98 (2.76, 3.22) | < .0001 | ||||
| (Detailed Subtype) | ||||||
| High-Grade Endometrioid | 2.70 (2.48, 2.94) | < .0001 | NA | 1 (Reference) | ||
| Clear Cell | 3.00 (2.43, 3.70) | < .0001 | 1.10 (0.90, 1.34) | 0.352 | ||
| Carcinosarcoma | 5.03 (4.48, 5.66) | < .0001 | 1.89 (1.70, 2.10) | < .0001 | ||
| Mixed high-grade | 2.53 (2.18, 2.93) | < .0001 | 0.92 (0.80, 1.05) | 0.216 | ||
| Serous | 3.07 (2.74, 3.44) | < .0001 | 1.15 (1.04, 1.27) | 0.007 |
sHR: subdistribution hazard ratio. HR: hazard ratio. 95%CI: 95% confidence interval. P: two-sided p-value. NA: not applicable.
Year of diagnosis was included in all models as a categorical variable.