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. 2020 May 13;41(28):2668–2677. doi: 10.1093/eurheartj/ehaa293

Table 3.

Outcome in BMI subgroups, Cox regression models (HR, 95% confidence intervals) adjusted for age and sex (upper line) and full adjustment (lower line); BMI category 22–24.9 kg/m2 was used as reference category

BMI <22
 25–29.9  
 30–34.9  
 35–39.9  
 ≥40 kg/m2  
Outcomes HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value
All-cause mortality
 Age and sex adjusted 1.28 1.03–1.60 0.029 0.80 0.70–0.92 0.001 0.83 0.72–0.96 0.011 0.94 0.77–1.14 0.518 1.02 0.77–1.35 0.876
 Full adjustment 1.29 1.01–1.65 0.038 0.79 0.68–0.91 0.002 0.75 0.61–0.93 0.008 0.65 0.46–0.92 0.014 0.81 0.50–1.32 0.395
CV mortality
 Age and sex adjusted 1.31 0.99–1.74 0.056 0.78 0.66–0.93 0.006 0.79 0.66–0.96 0.015 0.80 0.62–1.04 0.099 0.96 0.67–1.38 0.833
 Full adjustment 1.35 1.00–1.83 0.048 0.81 0.67–0.98 0.033 0.69 0.53–0.89 0.005 0.59 0.38–0.92 0.020 0.68 0.36–1.26 0.217
Primary composite endpointa
 Age and sex adjusted 1.13 0.90–1.42 0.278 0.86 0.75–0.98 0.023 0.79 0.68–0.91 0.001 0.87 0.72–1.06 0.163 0.83 0.63–1.10 0.189
 Full adjustment 1.24 0.97–1.58 0.090 0.88 0.76–1.02 0.089 0.70 0.57–0.85 0.001 0.69 0.49–0.96 0.029 0.68 0.42–1.11 0.122
Expanded composite endpointb
 Age and sex adjusted 0.95 0.78–1.16 0.637 0.96 0.87–1.07 0.449 0.98 0.88–1.10 0.763 1.03 0.89–1.19 0.718 0.86 0.70–1.07 0.190
 Full adjustment 1.03 0.83–1.27 0.798 0.95 0.85–1.070 0.421 0.86 0.74–1.01 0.072 0.86 0.66–1.12 0.254 0.78 0.53–1.12 0.217

Full adjustment for age, sex, ever smoker, previous cardiovascular event, LDL, HbA1c, eGFR, allocation to glargine, allocation to omega 3 fatty acid, duration of DM, waist circumference, systolic blood pressure, ACE or ARB medication, beta-blocker medication, statin medication. Hip circumference, hypertension and diastolic blood pressure were not included in the model because of collinearity.

a

Primary composite endpoint: composite of first occurrence of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke.

b

Expanded composite endpoint: composite of first occurrence of these three outcomes or revascularization or heart failure hospitalization.