Schematic overview of Golgi-ER and plasma membrane-organelle interactions and their physiological relevance. CERT, Ceramide Transport Protein; FAPP1, Phosphatadyl-four-phosphate-adaptor protein 1; ER, Endoplasmic Reticulum; GOLGI, Golgi Apparatus; Mdm36, Mitochondrial distribution and morphology protein 36; MECA, Mitochondria-ER cortex anchor; MITO, Mitochondrion; Num1, Nuclear migration protein 1; Orai1, Calcium release-activated calcium channel protein 1; Orp9/10/11, Oxysterol-binding protein related protein 9/10/11; Osbp1, Oxysterol-binding protein 1; Osh2/3/6/7, Oxysterol-binding protein homology 2/3/6/7; PI(4)P, Phosphatidylinositol-4-phosphate; Sac1, suppressor of actin 1; Scs2, suppressor of chromosome segregation protein 1 (CSE1) 2; STIM1, Stromal Interaction Molecule 1; VAP, Vesicle-Associated Membrane Protein (VAMP)-associated Protein.