Table 1. Echocardiograph results of LVEDV, LVEDD, LVESV, LVESD, LVEEF and LVEFS by echocardiography.
| Group | LVEDV (μL) | LVEDD (mm) | LVESV (μL) | LVESD (mm) | LVEEF (%) | LVEFS (%) |
| Sham | 216.12 ± 18.37 | 5.47 ± 0.23 | 85.45 ± 7.46 | 3.12 ± 0.28 | 60.29 ± 4.29 | 42.94 ± 4.67 |
| I/R | 400.23 ± 32.38* | 11.49 ± 1.11* | 287.46 ± 25.38* | 10.23 ± 1.03* | 28.18 ± 2.68* | 10.98 ± 1.10* |
| I/R + sh-NC | 401.83 ± 24.18 | 12.35 ± 1.05 | 284.88 ± 22.35 | 11.16 ± 0.95 | 29.12 ± 3.09 | 9.61 ± 0.83 |
| I/R + sh-TXNIP | 285.49 ± 24.39# | 8.18 ± 0.47# | 165.42 ± 17.56# | 5.84 ± 0.47# | 41.98 ± 4.79# | 28.65 ± 3.04# |
| I/R + EVagomir-NC | 380.48 ± 26.90 | 11.58 ± 0.34 | 259.96 ± 29.23 | 10.19 ± 0.41 | 31.84 ± 3.09 | 12.02 ± 1.49 |
| I/R + EVmiR-150-5p-agomir | 274.35 ± 19.78& | 7.95 ± 0.55& | 161.13 ± 15.83& | 6.00 ± 0.54& | 41.34 ± 2.09& | 24.50 ± 2.65& |
| I/R + EVmiR-150-5p-agomir + oe-TXNIP | 416.01 ± 19.97$ | 11.59 ± 0.32$ | 301.12 ± 22.14$ | 10.20 ± 0.39$ | 27.63 ± 3.61$ | 11.99 ± 1.49$ |
Note: * p < 0.05 vs. the sham group (sham-operated rats); # p < 0.05 vs. the I/R + sh-NC group (I/R rats treated with sh-NC); & p < 0.05 vs. the I/R + EVagomir-NC group (I/R rats treated with EVagomir-NC); $ p < 0.05 vs. the I/R + EVmiR-150-5p-agomir group (I/R rats treated with EVmiR-150-5p-agomir). The measurement data were expressed as mean ± standard deviation. Comparison among multiple groups was conducted using one-way analysis of variance, followed by Tukey’s post hoc test. I/R, ischemia/reperfusion; NC, negative control; TXNIP, thioredoxin-interacting protein; miR, microRNA; LVEDV, left ventricular end-diastolic volume; LVEDD, left ventricular end-diastolic dimension; LVESV, left ventricular end-systolic volume; LVESD, left ventricular end-systolic dimension; LVEEF, left ventricular ejection fraction; LVEFS, left ventricular fractional shortening.