Table 3. Neurocognitive function repeated measures analysis.

	Main Effect of Group		Main Effect of Time		Interaction Effect (Group_by_Time)
	F	p-value	F	p-value	F	p-value
Neurotrax
Primary Endpoint
Global Cognitive Score	7.171	0.009*	34.382	<0.000*	10.811	0.002*
Secondary Endpoints
Memory	0.256	0.614	7.069	0.010*	5.186	0.026
Verbal – Immediate	0.195	0.66	4.602	0.036	0.220	0.64
Verbal - Delayed	4.61	0.036	5.732	0.02	1.216	0.274
Non-verbal - Immediate	5.511	0.002*	0.33	0.567	4.512	0.037
Non-verbal – Delayed	3.874	0.053	1.472	0.229	4.400	0.04
Executive Function	17.321	<0.000*	9.346	0.003*	2.213	0.142
Attention	8.688	0.004*	18.2	<0.000*	8.445	0.005*
Information Processing Speed	5.634	0.021*	8.082	0.006*	9.142	0.003*
Motor Skills	5.526	0.022*	1.781	0.187	2.964	0.09
CANTAB
ASTLCM	12.716	0.001*	3.408	0.07	4.458	0.039
ASTLCMD	8.980	0.004*	0.033	0.857	10.702	0.002*
ASTLICM	10.563	0.002*	5.488	0.023	6.146	0.016
ASTLICMD	11.183	0.001*	2.262	0.138	11.254	0.001*
Pen and Paper
RAVLT Total Z-Score	0.059	0.809	6.876	0.011	5.439	0.023
Five Points (Percentile)	2.400	0.127	16.641	<0.000	1.778	0.188
F-A-S Z-Score (Semantic)	1.449	0.234	1.233	0.271	4.646	0.035

Using a 2X2 repeated measures ANOVA model, the cognitive scores were compared between the 2 groups.

The first two columns present the between group effect. The 3^rd and 4^th columns report the time repeated effect (within group). The 5^th and 6^th columns report the group-by-time interaction;

Bold – P<0.05, *-Satisfied Bonferroni corrections;

Neurotrax scores are normalized to age, gender and education years.