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. 2020 Jul 1;12(13):12750–12770. doi: 10.18632/aging.103177

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Copyright © 2020 Yang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The presence of senescent human chondrocytes (SnCs) in adjacent normal and advanced osteoarthritic articular cartilage. (A) Representative images of HMGB1-positive non-SnCs (brown staining at red arrows, scale bars, 100 μm) by immunohistochemistry and SA-β-gal-positive SnCs expression on OA articular cartilage, OA chondrocytes (P0) and adjacent normal cartilage. (B) The statistical analysis of the percentage of SA-β-gal and HMGB1 positive cells from three independent experiments. Scale bar: 100 μm.