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. 2020 Jul 8;12(13):13220–13233. doi: 10.18632/aging.103429

Figure 5.

Figure 5

High level of GGT5 in CAFs decreases the ROS level of LUAD cells. (A) The GGT activity in paired NFs and CAFs was tested in vitro (n = 6). (B) The level of GSH in NFs and CAFs or their conditioned media (NFs-M and CAFs-M) was detected. (C) The extracellular cysteine or glutamate in NFs-M and CAFs-M were analyzed respectively. (D) The relative intracellular GSH in A549 and LAC1 cells treated with different media: Normal-M, NFs-M or CAFs-M. (E) The relative intracellular ROS in A549 and LAC1 cells treated with different media. (F) The relative intracellular GSH in A549 and LAC1 cells treated with Vector-M or GGT5-M. (G) The relative intracellular ROS in A549 and LAC1 cells treated with Vector-M or GGT5-M. In all panels, data represent mean ± SEM. ns, no significant difference. *, P < 0.05; **, P < 0.01; ***, P < 0.001.