Table 3. Multivariate associations of circFOXO3 rs12196996 polymorphism with CAD risk by further stratification analysis.
| Variable | Allele | Controls No. (%) | Cases No. (%) | OR (95% CI) | P |
| Age a | |||||
| Age≤60 | A | 430 (85.7) | 368 (80.0) | 1.00 | - |
| G | 72 (14.3) | 92 (20.0) | 1.82 (1.19-2.76) | 0.005 | |
| Age>60 | A | 593 (82.6) | 550 (79.7) | 1.00 | - |
| G | 125 (17.4) | 140 (20.3) | 1.16 (0.85-1.57) | 0.350 | |
| Genderb | |||||
| Male | A | 616 (83.5) | 652 (79.9) | 1.00 | - |
| G | 122 (16.5) | 164 (20.1) | 1.26 (0.93-1.71) | 0.142 | |
| Female | A | 407 (84.4) | 266 (79.6) | 1.00 | - |
| G | 75 (15.6) | 68 (20.4) | 1.49 (0.98-2.26) | 0.062 | |
| Smokingc | |||||
| Yes | A | 240 (86.3) | 510 (80.7) | 1.00 | - |
| G | 38 (13.7) | 122 (19.3) | 1.30 (0.85-1.98) | 0.226 | |
| No | A | 783 (83.1) | 408 (78.8) | 1.00 | - |
| G | 159 (16.9) | 110 (21.2) | 1.37 (1.02-1.85) | 0.039 | |
| Drinkingd | |||||
| Yes | A | 109 (83.8) | 215 (79.0) | 1.00 | - |
| G | 21 (16.2) | 57 (21.0) | 1.11 (0.57-2.19) | 0.755 | |
| No | A | 914 (83.9) | 703 (80.1) | 1.00 | - |
| G | 176 (16.1) | 175 (19.9) | 1.35 (1.04-1.76) | 0.026 |
a Adjusted for gender, smoking, drinking, hypertension, diabetes, hyperlipidemia.
b Adjusted for age, smoking, drinking, hypertension, diabetes, hyperlipidemia.
c Adjusted for age, gender, drinking, hypertension, diabetes, hyperlipidemia.
d Adjusted for age, gender, smoking, hypertension, diabetes, hyperlipidemia.