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Structure of the DIR2s aptamer. Cartoon representation of DIR2s aptamer bound to OTB-SO3 (green sticks). Nucleotides composing the ligand platform are colored orange and yellow and the adenine lid (A40) is colored blue. Dashed box denotes the Fab binding loop used to facilitate crystallization. (b) Ligand binding pocket of the DIR2s aptamer (ball-and-stick) bound to OTB-SO3 (green ball-and-stick). (c) Overlay of the Apo-DIR2s structure with DIR2s-OTB-SO3 (transparent).
