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. Author manuscript; available in PMC: 2021 Jun 18.
Published in final edited form as: Mol Cell. 2020 Jun 5;78(6):1207–1223.e8. doi: 10.1016/j.molcel.2020.05.015

Figure 7. INCR1 interaction with HNRNPH1 regulates PD-L1 expression and IFNγ signaling.

Figure 7.

(A) In cells not stimulated with IFNγ, HNRNPH1 (H1) binds PD-L1 (blue) and JAK2 (green) transcripts to negatively regulate their expression.

(B) In response to IFNγ stimulation, INCR1 is transcribed from the PD-L1 locus. INCR1 binds HNRNPH1 to enable PD-L1 (blue) and JAK2 (green) expression and promote IFNγ-mediated immunosuppression.