TABLE 1.
The subtype, marks and feature of macrophages
| Macrophage | M1 | M2 | M4 | Mox | M(Hb) | Mhem | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| M2a | M2b | M2c | M2d | |||||||
| Markers | CD11a/b/c, CD14/15/16/33/64/32/68/80/85k/86/107b/115/163, CCR5, Mac‐2, GITR Ligand, HLA‐DR, MHCⅡ,TLR2/4, EMR1(Human), F4/80(Mouse) | CD16/32/36/68/80/86+,CD163‐, IFN‐γR+,MHCⅡhigh; COX2+, INOS+,IRF5+, STAT1+ | CD163/200/209/206/301+,CXCR1/2+, Dectin‐1+, IL‐1RⅡ+, MHCⅡlow, Arg1+(Mouse), IRF4+, PPARγ+, STAT6+ | CD86+, IL‐4 Rα+, IFN‐γ R+, MHCⅡ+, COX2+, SOCS3+, IRF4+, Sphingosine Kinase 1/2+ | CXCR2+, CD150/163/206/301+, IL‐4 Rα+, MSR+, SR‐B1+, TLR1+, Arg1+(Mouse), IRF4+, SOCS3+, TLR8+ | INOS+ | Unknown | |||
| Inducer | LPS, IFNγ, TNFα, OXLDL | IL‐4, IL‐13 | Immune complex + IL‐1R/TLR ligands | IL‐10, TGF‐β | TLR Agonists + Adenosine | CXCL4 | OxPL | Haemoglobin/Haptoglobin Complex | Heme | |
| Feature | Pro‐Inflammatory | Anti‐Inflammatory | Anti‐Inflammatory | Anti‐Inflammatory | Wound Healing& Angiogenesis | Pro‐Inflammatory | Anti‐Oxidant |
Anti‐Inflammatory Atheroprotective |
||