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. 2020 Jun 17;53(7):e12809. doi: 10.1111/cpr.12809

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© 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of metformin on the spindle assembly and chromosome alignment in the arecoline‐exposed oocytes. A, Representative pictures of spindle morphologies and chromosome alignment in the control, Are and Are + Met groups. Spindle (green) and chromosome (blue). Scale bar = 10 μm. B, The rates of aberrant spindles in the control, Are and Are + Met groups. C, The rates of misaligned chromosomes in the control, Are and Are + Met groups. Data were presented as mean ± SD. ^a‐bMeans not sharing a common superscript are different (P < .05)