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. 2020 Jul 23;10:12368. doi: 10.1038/s41598-020-69296-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Klotho attenuates lung and heart fibrosis. Masson’s trichrome staining of (a) lung and (b) right ventricle sections demonstrating decreased fibrosis in hyperoxia-exposed Klotho treated rats. Original magnification × 20, Scale bars are 50 µm. Klotho supplementation in hyperoxia-exposed rats decreased (c) lung, (d) RV and (e) LV TGF-β expression. Representative Western blots are shown in the lower panels. Lung TGF-β expression is normalized to β-Actin. RV and LV TGF-β expression is normalized to GAPDH. White bars indicate normoxia, and black bars indicate hyperoxia (Data are mean ± SEM; P < 0.05; * normoxia-PL vs hyperoxia-PL; † hyperoxia-PL vs hyperoxia-Klotho; N = 5/group).