Table 2.
Over-representation analysis of co-expressed genes with hub miRNA using EO-PCa data.
| hub miRNA | Gene set | Size | Expect | Ratio | Overlap | FDR |
|---|---|---|---|---|---|---|
| hsa_miR_142_5p | WALLACE PROSTATE CANCER RACE UP | 277 | 3.64 | 4.12 | 15 | 1.0889E−06 |
| hsa_miR_150_5p | WALLACE PROSTATE CANCER RACE UP | 277 | 2.32 | 3.88 | 9 | 8.83E−04 |
| hsa_miR_142_5p | Ding Early onset prostate cancer 2016 | 158 | 2.08 | 5.78 | 12 | 1.0889E−06 |
| hsa_miR_150_5p | Ding Early onset prostate cancer 2016 | 158 | 1.32 | 6.81 | 9 | 1.46E−05 |
| hsa_miR_146b_3p | Ding Early onset prostate cancer 2016 | 158 | 6.89 | 4.93 | 34 | 3.12E−13 |
| hsa_miR_3545_3p | LIU PROSTATE CANCER DN | 473 | 5.65 | 2.30 | 12 | 0.015 |
Only statistically significant associations are shown. Size means the number of genes in the pathway. Expect means the expected number of genes in the pathway co-expressed by chance with the miRNA. Ratio means the additional number of times that there are more genes co-expressed with the miRNA compared with the expected number. Overlap means the number of co-expressed genes that are part of the pathway. FDR is the false discovery rate of the overlap.