Table 2.
HADS-depression scores at baseline (t1), after 1 month (t2), 6 months (t3), 12 months (t4), 18 months (t5) and 2 years (t6) by the 5-HTTLPR (A) and ACE (B) genotype
| A | Total study population | 5-HTTLPR D/D | 5-HTTLPR I/D | 5-HTTLPR I/I | p value |
|---|---|---|---|---|---|
| HADS depression t1 | 10.4 ± 2.5 (n = 507) | 10.6 ± 2.8 (n = 104) | 10.3 ± 2.3 (n = 237) | 10.5 ± 2.7 (n = 166) | 0.425 |
| HADS depression t2 | 9.8 ± 3.9 (n = 452) | 10.2 ± 4.2 (n = 90) | 9.6 ± 3.7 (n = 207) | 9.9 ± 4.0 (n = 155) | 0.494 |
| HADS depression t3 | 8.9 ± 3.9 (n = 420) | 9.3 ± 4.4 (n = 84) | 8.6 ± 3.8 (n = 193) | 9.2 ± 3.6 (n = 143) | 0.247 |
| HADS depression t4 | 8.6 ± 4.0 (n = 394) | 8.6 ± 4.4 (n = 81) | 8.3 ± 3.8 (n = 173) | 8.9 ± 4.1 (n = 140) | 0.398 |
| HADS depression t5 | 8.1 ± 3.9 (n = 378) | 7.9 ± 4.1 (n = 72) | 7.9 ± 3.8 (n = 172) | 8.4 ± 3.8 (n = 134) | 0.516 |
| HADS depression t6 | 8.3 ± 4.0 (n = 372) | 7.7 ± 4.2 (n = 73) | 8.4 ± 4.0 (n = 170) | 8.4 ± 3.9 (n = 129) | 0.379 |
| B | ACE D/D | ACE I/D | ACE I/I | p value |
|---|---|---|---|---|
| HADS depression t1 | 10.6 ± 2.6 (n = 140) | 10.5 ± 2.6 (n = 252) | 10.1 ± 2.4 (n = 115) | 0.317 |
| HADS depression t2 | 10.3 ± 3.9 (n = 125) | 9.6 ± 4.0 (n = 224) | 9.7 ± 3.8 (n = 103) | 0.277 |
| HADS depression t3 | 9.5 ± 3.9 (n = 114) | 8.8 ± 3.9 (n = 208) | 8.6 ± 3.9 (n = 98) | 0.217 |
| HADS depression t4 | 9.3 ± 4.2 (n = 109) | 8.4 ± 3.9 (n = 201) | 8.2 ± 4.0 (n = 84) | 0.087 |
| HADS depression t5 | 8.5 ± 4.1 (n = 102) | 8.0 ± 3.9 (n = 190) | 7.9 ± 3.6 (n = 86) | 0.527 |
| HADS depression t6 | 9.0 ± 4.1 (n = 102) | 8.2 ± 4.1 (n = 184) | 7.6 ± 3.6 (n = 86) | 0.047 |
Bold p values are less than 0.05