Table 3.

Tracer uptake in autoradiography for all glioma models quantified by SUV (mean ± SD) and tumor-to-brain ratios (TBR, mean ± SD). SUV in the center of the tumors was significantly higher for ⁶⁸Ga-PSMA than for ¹⁸F-DCFPyL in all tumor models. Furthermore, the TBR of tracer uptake at the tumor rim was significantly higher for ¹⁸F-DCFPyL than for ⁶⁸Ga-PSMA in all tumor models. The differences have to be interpreted carefully, since the data may be influenced by the different spatial resolution when using ⁶⁸Ga or ¹⁸F

Model	Parameter	Region	68Ga-PSMA	18F-DCFPyL	p value
U87	SUV	Tumor center	0.39 ± 0.09	0.22 ± 0.08	0.005
		Tumor rim	0.77 ± 0.13	0.87 ± 0.13	n.s.
		Brain	0.016 ± 0.004	0.004 ± 0.002	n.s.
	TBR	Tumor center	25.1 ± 2.1	58.4 ± 13.1	n.s.
		Tumor rim	50.0 ± 13.1	256.2 ± 27.9	< 0.001
9 L	SUV	Tumor center	0.85 ± 0.08	0.37 ± 0.20	< 0.001
		Tumor rim	1.31 ± 0.28	0.85 ± 0.23	< 0.001
		Brain	0.013 ± 0.001	0.006 ± 0.004	n.s.
	TBR	Tumor center	64.43 ± 6.65	69.86 ± 19.86	n.s.
		Tumor rim	99.91 ± 23.17	181.17 ± 81.14	0.011
F98	SUV	Tumor center	0.43 ± 0.07	0.28 ± 0.02	0.006
		Tumor rim	0.78 ± 0.16	0.78 ± 0.09	n.s.
		Brain	0.013 ± 0.001	0.006 ± 0.002	n.s.
	TBR	Tumor center	34.10 ± 7.04	50.48 ± 20.79	n.s.
		Tumor rim	62.39 ± 16.57	139.84 ± 48.27	0.001