Table 4.

⁶⁸Ga-PSMA and ¹⁸F-DCFPyL uptake in tumor and contralateral brain in micro-PET for U87, 9 L, and F98 models (each group n = 5) quantified by SUV and TBR (mean ± SD). SUV in the brain was significantly higher for ⁶⁸Ga-PSMA than for ¹⁸F-DCFPyL in all tumor models leading to higher TBR for ¹⁸F-DCFPyL in all tumor models. The differences have to be interpreted carefully, since the data are influenced by the different spatial resolution when using ⁶⁸Ga or ¹⁸F

Model	Parameter	Region	[68Ga]PSMA	[18F] DCFPyL	p value
U87	SUV	Tumor	0.31 ± 0.05	0.32 ± 0.07	n.s.
		Brain	0.10 ± 0.02	0.05 ± 0.01	< 0.001
	TBR		3.26 ± 0.55	6.28 ± 0.68	< 0.001
9 L	SUV	Tumor	0.46 ± 0.09	0.56 ± 0.11	n.s.
		Brain	0.12 ± 0.01	0.07 ± 0.02	< 0.001
	TBR		3.92 ± 0.57	7.92 ± 1.99	< 0.001
F98	SUV	Tumor	0.39 ± 0.05	0.44 ± 0.04	n.s.
		Brain	0.12 ± 0.02	0.07 ± 0.01	< 0.001
	TBR		3.22 ± 0.50	6.85 ± 1.33	< 0.001