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. 2020 Jul 23;11:3692. doi: 10.1038/s41467-020-17183-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–d Volcano plots depicting acylcarnitines, glycerophospholipids, sphingolipids, sugars, bile acids, amino acids, and biogenic amines in liver tissue at PND14 vs. PND7 (a), PND21 vs. PND7 (b), PND28 vs. PND7 (c), and PND56 vs. PND7 (d) measured by mass spectrometry (n = 5 per group, two-tailed independent student’s t-test, fold-changes were calculated based on mean values by dividing the PNDx to PNDy concentrations and log2 the values). PND7 was selected as baseline for comparisons due to the high interindividual variation at PND1. e Principal Component Analysis (PCA) illustrating changes in the composition of the bile acid pool during the postnatal period. f–g Relative hepatic expression of the key-enzymes of (f) the classical (Cyp7a1, Cyp8b1, and Cyp27a1) and (g) the alternative and murine pathway (Cyp7b1, Cyp2c70, and Cyp27a1) (n = 5 per group, mean and SD). h Relative expression of Cyp7a1 in total liver tissue of germ-free (GF) and conventionally (CONV) raised mice (n = 5 per group, mean and SD). Source data are provided as a Source Data file.