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. 2020 Jul 23;11(7):562. doi: 10.1038/s41419-020-02785-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, b The mean tumor weight (g) and size (mm³) were analyzed. c Images of xenograft tumors in four different nude mouse groups. The red circle indicates lymph node metastasis in nude mice. d Expression of EMT-related proteins was detected by Western blot analysis. e Expression of IGFBP3, E-cadherin, N-cadherin, and vimentin were determined by immunohistochemistry. f Schematic illustration of the circ-0046263/miR-133a-5p/IGFBP3 axis. Values represent the mean ± SD of three independent experiments. *P < 0.05; **P < 0.01.