Skip to main content
. 2020 Jul 23;11(7):565. doi: 10.1038/s41419-020-02770-w

Fig. 1. Necroptosis is activated in the infarct area after MCAO/R.

Fig. 1

a Representative TTC-stained images of brain slices in WT mice in the sham group and the MCAO/R group. b Comparison of the percentages of infarct volume between the sham group and the MCAO/R group. Each symbol represents one male mouse (sham, n = 10; MCAO/R, n = 10). Bars indicate the means ± SEM; the P-value was determined using a t-test; ***P < 0.001. c–e Comparison of the neurological scores between the sham group and the MCAO/R group (n = 10): Longa score (c), general Clark score (d), and focal Clark score (e). Data in bar graphs are means ± SEM; t-test: ***P < 0.001. f mRNA expression of RIP1, RIP3, and MLKL in the infarct were increased area at 24 h after MCAO/R. Each symbol represents one male mouse (sham, n = 12; MCAO/R, n = 12). Bars indicate the means ± SEM; t-test: ***P < 0.001. g Increased levels of insoluble RIP1, RIP3, and MLKL were found in the mouse infarct area at 24 h after MCAO/R (n = 6).