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. 2020 Jul 23;40(7):BSR20200990. doi: 10.1042/BSR20200990

Table 5. Subgroup analysis of the associations of IGF2BP2 rs4402960 (G>T) polymorphisms with gestational diabetes mellitus.

Subgroup N Allele model (T vs. G allele) Dominant model (TT+GT vs. GG) Recessive model (TT vs. GG+GT) Heterozygous model (TT vs. GT) Homozygous model (TT vs. GG)
Test of association Test of heterogeneity Test of association Test of heterogeneity Test of association Test of heterogeneity Test of association Test of heterogeneity Test of association Test of heterogeneity
Odds ratio (95% CI) P I2 (%) P Odds ratio (95% CI) P I2 (%) P Odds ratio (95% CI) P I2 (%) P Odds ratio (95% CI) P I2 (%) P Odds ratio (95% CI) P I2 (%) P
Genotyping method
  TaqMan assay 5 1.07 (0.91–1.26) 0.410 71.7 0.007 1.08 (0.87–1.33) 0.491 72.0 0.006 1.15 (0.96–1.38) 0.135 37.3 0.173 1.06 (0.87–1.30) 0.552 67.4 0.015 1.16 (0.86–1.56) 0.321 54.6 0.066
  PCR-RFLP 2 0.78 (0.55–1.11) 0.164 33.1 0.222 0.65 (0.25–1.67) 0.368 80.4 0.024 0.64 (0.37–1.10) 0.107 28.6 0.237 0.64 (0.19–2.14) 0.468 86.8 0.006 0.63 (0.35–1.12) 0.115 0 0.628
Ethnicity
  Caucasian 3 0.99 (0.80–1.23) 0.949 52.9 0.120 1.02 (0.73–1.42) 0.906 65.8 0.053 0.91 (0.68–1.23) 0.550 46.8 0.153 1.04 (0.71–1.53) 0.837 71.4 0.030 0.93 (0.62–1.40) 0.722 38.3 0.198
  Asian 4 1.00 (0.78–1.28) 0.988 81.5 0.001 0.96 (0.70–1.32) 0.810 82.0 0.001 1.19 (0.96–1.47) 0.120 50.9 0.106 0.94 (0.69–1.29) 0.722 79.0 0.003 1.16 (0.75–1.79) 0.510 64.8 0.036
Control source
  Hospital-based 6 0.96 (0.80–1.16) 0.691 73.4 0.002 0.94 (0.72–1.23) 0.675 76.7 0.001 0.99 (0.80–1.22) 0.953 48.2 0.086 0.95 (0.92–1.25) 0.703 76.3 0.001 0.97 (0.69–1.37) 0.874 54.0 0.054
  Population-based 1 1.19 (1.02–1.39) 0.031 1.20 (0.98–1.47) 0.084 1.37 (0.97–1.92) 0.073 1.14 (0.92–1.42) 0.231 1.45 (1.02–2.08) 0.039

Abbreviations: CI, confidence interval; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism.