Table 5. Subgroup analysis of the associations of IGF2BP2 rs4402960 (G>T) polymorphisms with gestational diabetes mellitus.
| Subgroup | N | Allele model (T vs. G allele) | Dominant model (TT+GT vs. GG) | Recessive model (TT vs. GG+GT) | Heterozygous model (TT vs. GT) | Homozygous model (TT vs. GG) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Test of association | Test of heterogeneity | Test of association | Test of heterogeneity | Test of association | Test of heterogeneity | Test of association | Test of heterogeneity | Test of association | Test of heterogeneity | ||||||||||||
| Odds ratio (95% CI) | P | I2 (%) | P | Odds ratio (95% CI) | P | I2 (%) | P | Odds ratio (95% CI) | P | I2 (%) | P | Odds ratio (95% CI) | P | I2 (%) | P | Odds ratio (95% CI) | P | I2 (%) | P | ||
| Genotyping method | |||||||||||||||||||||
| TaqMan assay | 5 | 1.07 (0.91–1.26) | 0.410 | 71.7 | 0.007 | 1.08 (0.87–1.33) | 0.491 | 72.0 | 0.006 | 1.15 (0.96–1.38) | 0.135 | 37.3 | 0.173 | 1.06 (0.87–1.30) | 0.552 | 67.4 | 0.015 | 1.16 (0.86–1.56) | 0.321 | 54.6 | 0.066 |
| PCR-RFLP | 2 | 0.78 (0.55–1.11) | 0.164 | 33.1 | 0.222 | 0.65 (0.25–1.67) | 0.368 | 80.4 | 0.024 | 0.64 (0.37–1.10) | 0.107 | 28.6 | 0.237 | 0.64 (0.19–2.14) | 0.468 | 86.8 | 0.006 | 0.63 (0.35–1.12) | 0.115 | 0 | 0.628 |
| Ethnicity | |||||||||||||||||||||
| Caucasian | 3 | 0.99 (0.80–1.23) | 0.949 | 52.9 | 0.120 | 1.02 (0.73–1.42) | 0.906 | 65.8 | 0.053 | 0.91 (0.68–1.23) | 0.550 | 46.8 | 0.153 | 1.04 (0.71–1.53) | 0.837 | 71.4 | 0.030 | 0.93 (0.62–1.40) | 0.722 | 38.3 | 0.198 |
| Asian | 4 | 1.00 (0.78–1.28) | 0.988 | 81.5 | 0.001 | 0.96 (0.70–1.32) | 0.810 | 82.0 | 0.001 | 1.19 (0.96–1.47) | 0.120 | 50.9 | 0.106 | 0.94 (0.69–1.29) | 0.722 | 79.0 | 0.003 | 1.16 (0.75–1.79) | 0.510 | 64.8 | 0.036 |
| Control source | |||||||||||||||||||||
| Hospital-based | 6 | 0.96 (0.80–1.16) | 0.691 | 73.4 | 0.002 | 0.94 (0.72–1.23) | 0.675 | 76.7 | 0.001 | 0.99 (0.80–1.22) | 0.953 | 48.2 | 0.086 | 0.95 (0.92–1.25) | 0.703 | 76.3 | 0.001 | 0.97 (0.69–1.37) | 0.874 | 54.0 | 0.054 |
| Population-based | 1 | 1.19 (1.02–1.39) | 0.031 | – | – | 1.20 (0.98–1.47) | 0.084 | – | – | 1.37 (0.97–1.92) | 0.073 | – | – | 1.14 (0.92–1.42) | 0.231 | – | – | 1.45 (1.02–2.08) | 0.039 | – | – |
Abbreviations: CI, confidence interval; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism.