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. 2020 Jul 16;11:1281. doi: 10.3389/fimmu.2020.01281

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Copyright © 2020 Kong, Feng, Zhang, Liu, Ma, Zhao, Huang, Chen, Zhang, Thorsen, Wang, Yang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TREM1 is closely related to hypoxia and angiogenesis. TREM1 mRNA expression profiles based on pathological grade from (A) TCGA-Glioma and (B). Rembrandt-Glioma datasets. (C) Kaplan–Meier survival curves for GBM patients with TREM1^high and TREM1^low tumors using the Rembrandt database. (D) TREM1 mRNA expression levels in different GBM molecular subtypes. (E) TREM1 mRNA expression levels in non-GIMP and GIMP positive samples from the TCGA. (F) TREM1 mRNA expression levels in different pathologic areas/tumor microsections. Corresponding data were obtained from the Ivy Glioblastoma Atlas Project. Scatter plots displaying the correlation between TREM1 mRNA expression and protein levels of (G) IGFBP2, (H) TGM2, and (I) VEGFR2. (J) The results of representative GSEA analysis. (K) Chord diagram constructed from data on the correlation between TREM1 and immune co-stimulatory factor and checkpoint molecules. (L) Heatmap generated with TREM1 mRNA expression levels in multiple immune cells using the TCGA-GBM dataset. Significant difference between the two groups: *P < 0.05; **P < 0.01; ***P < 0.001.