Table 1.

Summary of case reports of laryngeal neuroendocrine neoplasms (NENs) with elevated serum levels of calcitonin.

References	Age, sex	bCT and sCT at diagnosis	Location of tumor	Treatment
Our case	59, M	bCT: 50 pg/ml (<10 pg/ml), sCT: 56.6 pg/ml (10 min after calcium gluconate test)	Epiglottis, 2 cervical lymph nodes, skin	TT, lymph node dissection, skin metastases excision, OCT 30 mg/28 days and Everolimus 10 mg/day
(11)	57, M	bCT: 157 pg/ml (0–8 pg/ml)	Right arytenoid, 7 cervical lymph nodes, and thyroid	Total laryngectomy, bilateral neck dissection, and TT
(2)	57, M	bCT: 599 pg/ml (reference range NA)	Epiglottis, cervical lymph nodes, skin nodules in the right arm, bones	Supraglottic laryngectomy, neck dissection, CHT
(12)	58, M	bCT: 48.9 pg/ml (<10 pg/ml)	Right aryepiglottic fold, six subcutaneous pre-laryngeal nodules, inner lower quadrant of left breast	Aryepiglottic cartilage resection, subcutaneous nodules excision
(10)	69, M	bCT: 970 pg/ml (<300 pg/ml)	Right arytenoid	Partial laryngectomy, RT, subtotal T
(13)	55, M	bCT: 3,790 pg/l (<100 pg/l), sCT: 6,378 pg/ml (5 min after pentagastrin administration)	Epiglottis, three submandibular lymph nodes, skin, brain	RT, CHT, submandibular lymph node resection, left neck dissection, total laryngectomy, skin, and cerebral metastases excision
(14)	54, M	bCT: 1,200 ng/L (<200 ng/l), sCT: 1,500 ng/l (3 min after pentagastrin administration)	Left arytenoid, three cervical lymph nodes	Laryngothyroidectomy

bCT, basal calcitonin level; sCT, stimulated calcitonin level; TT, total thyroidectomy; OCT, octreotide; T, thyroidectomy; CHT, chemotherapy; RT, radiotherapy.