Table 5.
| Coronary artery | <6 months old N (%) | ≥6 months old N (%) | p-value | OR (95% CI) |
|---|---|---|---|---|
| CLASSIFICATION BASED ON Z-MAX SCORE, EITHER LAD OR RCA | ||||
| Illness Day < = 10 days | ||||
| Normalb | 5/13 (38.5%) | 307/383 (80.2%) | 0.0015* | 0.15 (0.056 to 0.51) |
| Dilated Z-score ≥2.5 to ≤4 |
1/13 (7.7%) | 33/383 (8.6%) | >0.9999 | 0.88 (0.080 to 5.14) |
| Aneurysmal Z > 4 to ≤ 10 |
7/13 (53.8%) | 36/383 (9.4%) | 0.00012* | 11.25 (3.87 to 36.25) |
| Giant Aneurysm Z>10 |
0/13 (0.0%) | 7/383 (1.8%) | >0.9999 | - |
| First echo Z-score | 2.37 (1.02 to 5.08) | 0.77 (−0.03 to 1.72) | 0.0059* | - |
| Z-maxc | 4.55 (1.09 to 5.95) | 1.18 (0.19 to 2.07) | 0.0022* | - |
| Illness Day > 10 days | ||||
| Normalb | 0/4 (0.0%) | 49/81 (60.5%) | 0.03* | - |
| Dilated Z-score ≥2.5 to ≤4 |
0/4 (0.0%) | 9/81 (11.1%) | >0.9999 | - |
| Aneurysmal Z > 4 to ≤ 10 |
2/4 (50.0%) | 17/81 (21.0%) | 0.21 | 3.77 (0.55 to 24.87) |
| Giant Aneurysm Z>10 |
2/4 (50.0%) | 6/81 (7.4%) | 0.043* | 12.50 (1.62 to 84.97) |
| First Echo Z-score |
10.35 (5.73 to 14.50) | 1.65 (0.31 to 4.31) | 0.0064* | - |
| Z-maxc | 8.04 (5.32 to 15.38) | 1.86 (0.54 to 4.38) | 0.0045* | - |
Data expressed as N (%) or median (IQR); Fisher's exact test, two sided.
Subjects were classified as having normal (<2.5 standard deviation units [Z-score] from the mean, normalized for body surface area), dilated (Z-score ≥2.5 to ≤4), or aneurysmal (Z > 4 to ≤ 10 for giant aneurysm) coronary arteries on the basis of the maximal internal diameters of the right coronary artery (RCA) and left anterior descending artery (LAD) measured by echocardiography at the time of diagnosis and up to 8 weeks after onset of fever. Coronary artery abnormalities were classified as normal, dilated or aneurysmal (focal dilation of an arterial segment at least 1.5 times the diameter of the adjacent segment) based on the AHA 2004 KD Guidelines, as those were the published guidelines at the time of data collection.
Z max defined as largest Z score of LAD or RCA in the first 6 weeks of illness.
Unavailable CAA data for N = 495 (<6mo = 19, ≥6mo = 476).
Available Z-score data on N = 489 (<6mo = 18, ≥6mo = 471), however, only Z-scores data on N = 481 (<6mo = 17, ≥6mo = 464) were used for CAA analysis. Subjects with Z-scores, but without a verified height and weight or illness day were excluded from the CAA analysis.
Indicates statistical significance (p < 0.05).