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. 2020 Jul 16;8:388. doi: 10.3389/fped.2020.00388

Table 3.

Pediatric Plasma Cytokines.

95% CI
Mean SD Lower Upper Median Range Number of samples
GM-CSF (pg/mL)
<1 wk 9.903 7.085 5.143 14.66 6.89 2.23–23.1 11
1–2 wks 16.86 6.274 12.65 21.08 15.08 7.59–25.89 11
12–16 wks 12.95 7.805 9.393 16.5 10.84 3.67–31.89 21
20–24 wks 8.302 4.923 5.326 11.28 9.31 0.59–15.7 13
52 wks 14.16 6.935 8.364 19.96 12.01 5.7–27.72 8
5–15yrs 66.09 213.4 5.452 126.7 4.56 0–1,086 50
TGFα (pg/mL)
<1 wk 5.905 3.663 3.443 8.366 4.62 1.82–13.74 11
1–2 wks 6.107 2.116 4.686 7.529 5.81 2.78–9.68 11
12–16 wks 11.59 9.646 6.631 16.55 5.74 2.5–31.89 17
20–24 wks 5.097 3.518 3.149 7.046 4.58 1.55–14.95 15
52 wks 8.01 3.588 5.01 11.01 8.965 2.22–12.59 8
5–15yrs 7.635 6.788 5.404 9.866 5.94 0–28.68 38
G-CSF (pg/mL)
<1 wk 45.68 35.47 21.86 69.51 35.22 10.65–114.6 11
1–2 wks 66.81 35.54 42.93 90.68 59.47 22.14–135.5 11
12–16 wks 36.59 17.91 27.68 45.5 33.64 16.73–79.76 18
20–24 wks 33.05 26.01 19.68 46.42 31.41 0–100.4 17
52 wks 38.69 26.37 16.65 60.73 38.34 11.43–76.1 8
5–15yrs 77.33 87.95 52.07 102.6 50.54 0–272.8 49
IFNγ (pg/mL)
<1 wk 9.208 9.413 2.884 15.53 7.64 0–23.14 11
1–2 wks 19.59 11.92 11.59 27.6 19.17 0–37.83 11
12–16 wks 24.45 18.94 15.03 33.87 17.46 0–61.6 18
20–24 wks 16.04 14.11 8.782 23.29 18.72 0–40.82 17
52 wks 21.23 12.17 11.05 31.4 18.55 8.36–47.69 8
5–15yrs 27.35 23.64 20.64 34.07 22.6 0–78.09 50
IL-2 (pg/mL)
<1 wk 41.92 11.78 34.01 49.84 41.21 22.49–61.77 11
1–2 wks 43.82 15.78 33.22 54.43 39.53 20.16–75.84 11
12–16 wks 28.91 8.37 24.45 33.37 27.71 13.88–44.39 16
20–24 wks 28.14 11.69 22.13 34.15 25.63 13.43–55.52 17
52 wks 23.4 6.217 18.2 28.59 21.32 17.1–37.05 8
5–15yrs 72.5 71.21 52.04 92.95 44 1.78–234.1 49
IL-10 (pg/mL)
<1 wk 85.75 30.7 65.13 106.4 91.34 35.06–128.9 11
1–2 wks 123 57.6 84.26 161.6 103.9 56.84–252.6 11
12–16 wks 82.07 31.25 66.53 97.61 77.73 40.86–160.1 18
20–24 wks 64.9 37.21 45.77 84.03 61.91 22.73–183 17
52 wks 74.02 29.73 49.17 98.88 65.84 31.55–126.2 8
5–15yrs 4.556 5.425 3.03 6.081 2.64 0–25.93 51
IL-15 (pg/mL)
<1 wk 15.31 6.519 10.93 19.69 12.7 9.31–30.28 11
1–2 wks 12.01 3.051 9.965 14.06 12.15 6.33–17.47 11
12–16 wks 10.83 2.222 9.642 12.01 10.32 7.33–14.86 16
20–24 wks 7.191 2.477 5.761 8.621 6.76 1.82–11.04 14
52 wks 9.888 2.854 7.501 12.27 10.32 5.57–14.04 8
5–15yrs 11.56 9.229 8.939 14.18 8.115 1.24–40.49 50
sCD40L (pg/mL)
<1 wk 2,354 1,982 935.7 3,771 1,968 255.5–6,280 10
1–2 wks 1,014 631 528.7 1,499 951.9 226.6–1,876 9
12–16 wks 831.4 492.7 558.6 1,104 750.6 247.9–1,773 15
20–24 wks 713.6 513.1 449.8 977.4 549.3 60.53–1,827 17
52 wks 335 284.5 71.85 598.1 296.5 61.47–784.1 7
5–15yrs 1,965 3,225 919.7 3,011 548.1 66.83–10,000 39
IL-17 (pg/mL)
<1 wk 1.735 0.8546 1.161 2.31 1.63 0.76–3.51 11
1–2 wks 2.966 1.604 1.732 4.199 2.38 1.08–5.19 9
12–16 wks 1.573 0.685 1.113 2.033 1.46 0.8–3.31 11
20–24 wks 1.628 0.8263 1.103 2.153 1.32 0.64–3.36 12
52 wks 1.179 0.3899 0.8528 1.505 1.13 0.54–1.69 8
5–15yrs 3.079 6.146 1.333 4.826 1.04 0–30.32 50
IL-1ra (pg/mL)
<1 wk 45.7 19.9 30.4 60.99 37.61 28.16–82.87 9
1–2 wks 35.85 13.3 26.34 45.37 36.98 16.47–55.85 10
12–16 wks 30.18 10.63 24.29 36.07 26.95 15.08–53.95 15
20–24 wks 31.58 16.71 22.33 40.83 33.65 9.77–62.31 15
52 wks 23.61 6.197 17.88 29.34 20.34 18.24–34.16 7
5–15yrs 218.3 385.6 108.7 327.9 35.06 0–1,774 50
IL-13 (pg/mL)
<1 wk 33.36 9.062 27.27 39.45 35.32 17.55–46.58 11
1–2 wks 44 11.6 36.2 51.79 43.23 28.23–65.5 11
12–16 wks 46.68 17.9 36.77 56.6 46.33 27.84–89.72 15
20–24 wks 45.17 22.19 32.89 57.46 37.87 13.93–91.1 15
52 wks 39.74 6.744 34.1 45.38 40.98 31.33–48.42 8
5–15yrs 2.905 3.895 1.642 4.168 2.5 0–23.78 39
IL-4 (pg/mL)
<1 wk 20.01 24.83 3.335 36.69 16.22 0–75.79 11
1–2 wks 58.3 81.14 3.793 112.8 8.99 0–214.9 11
12–16 wks 8.501 8.973 3.32 13.68 7.895 0–26.43 14
20–24 wks 21.63 21.3 8.759 34.51 16.22 0–65.36 13
52 wks 30.15 36.77 −0.5928 60.89 22.6 0–106.2 8
5–15yrs 84.95 153.7 41.28 128.6 0 0–396.5 50
IL-1β (pg/mL)
<1 wk 1.836 0.9981 1.166 2.507 1.94 0.35–3.41 11
1–2 wks 3.33 1.338 2.431 4.229 3.1 1.77–6.02 11
12–16 wks 2.733 1.06 2.168 3.297 2.75 1.34–4.91 16
20–24 wks 1.844 1.01 1.26 2.427 1.67 0.81–4.22 14
52 wks 2.443 0.8683 1.717 3.168 2.37 1.02–3.95 8
5–15yrs 10.01 14.25 5.965 14.06 3.205 0–44.84 50
IL-5 (pg/mL)
<1 wk 6.608 4.863 3.129 10.09 5.19 1.8–18 10
1–2 wks 10.07 4.835 6.825 13.32 8.89 4.13–18.23 11
12–16 wks 7.263 2.561 5.946 8.58 8.07 3.33–10.76 17
20–24 wks 7.178 4.843 4.496 9.86 6.28 1.55–19.88 15
52 wks 5.361 1.895 3.609 7.114 5.42 1.86–7.46 7
5–15yrs 2.932 4.465 2.012 3.851 1.2 0–19.77 93
IL-6 (pg/mL)
<1 wk 4.376 2.751 2.528 6.224 4.48 0.83–9.15 11
1–2 wks 4.443 2.098 3.034 5.852 4.33 1.73–8.45 11
12–16 wks 2.828 1.553 2.001 3.655 2.475 0.93–6.85 16
20–24 wks 2.198 1.717 1.161 3.236 2.07 0.22–6.51 13
52 wks 2.576 1.06 1.69 3.463 2.405 0.97–3.95 8
5–15yrs 3.591 4.166 2.382 4.801 2.32 0–16.15 48
IL-8 (pg/mL)
<1 wk 233.1 106.7 143.9 322.3 243.8 52.3–374.2 8
1–2 wks 734.5 730.2 243.9 1,225 478.6 37.28–2,430 11
12–16 wks 329.8 207.1 223.3 436.3 283.7 77.06–747.5 17
20–24 wks 184.3 125.5 111.8 256.7 147.4 36.68–416.9 14
52 wks 192.4 96.2 111.9 272.8 189.7 94.38–343.4 8
5–15yrs 1,084 1,625 622.2 1,546 452.8 0–6,827 50
TNFα (pg/mL)
<1 wk 48.95 33.77 26.26 71.64 39.64 12.69–113.1 11
1–2 wks 91.2 31.58 69.98 112.4 82.58 47.41–137.4 11
12–16 wks 88.2 33.86 70.79 105.6 92.95 38.75–149.9 17
20–24 wks 69.45 47.06 43.39 95.51 58.49 12.11–168.8 15
52 wks 82.66 37.46 51.34 114 79.56 37.01–150.5 8
5–15yrs 26.54 33.83 16.92 36.15 13.41 0–107.2 50
IL-12/23p40 (pg/mL)
<1 wk 27.77 24.62 11.23 44.32 20.51 0–71.75 11
1–2 wks 60.06 27.07 41.87 78.24 53.12 21.09–98.56 11
12–16 wks 41.53 15.68 32.06 51.01 39.67 19.72–67.79 13
20–24 wks 49.59 50.48 19.08 80.1 34.92 0–149 13
52 wks 43.98 23.64 24.21 63.74 40.05 16.98–96.27 8
5–15yrs 239.1 318.9 148.4 329.7 90.52 12.63–1,148 50
MIP-1α (pg/mL)
<1 wk 19.58 6.885 14.95 24.2 22.25 8.29–27.5 11
1–2 wks 29.2 8.947 23.19 35.21 27.8 18.17–47.92 11
12–16 wks 30.78 14.42 22.79 38.76 25.99 15.61–66.18 15
20–24 wks 22.09 6.513 17.95 26.22 23.2 10.21–34.98 12
52 wks 23.83 6.502 18.39 29.26 23.63 16.54–35.77 8
5–15yrs 26.61 21.3 20.55 32.66 25.93 0–65.25 50
MIP-1β (pg/mL)
<1 wk 7.9 5.136 4.449 11.35 7.3 0.91–16.02 11
1–2 wks 13.71 5.369 10.1 17.32 13.48 6.99–22.01 11
12–16 wks 10.75 5.374 8.077 13.42 10.4 0–21.26 18
20–24 wks 6.772 2.258 5.408 8.137 6.32 3.14–10.05 13
52 wks 12.07 10.47 2.387 21.76 8.23 1.72–34.25 7
5–15yrs 18.33 17.84 13.26 23.4 13.11 0–75.98 50
MCP-1 (pg/mL)
<1 wk 707.2 371.7 457.5 957 529.7 382–1,508 11
1–2 wks 610.3 375.7 357.8 862.7 515.5 228.6–1,602 11
12–16 wks 284 75.88 245 323 265.6 150.3–429.3 17
20–24 wks 229 102.1 170 288 196.3 93.83–450.3 14
52 wks 252.3 81.48 184.2 320.4 230.7 160.7–422.5 8
5–15yrs 314.2 222.9 250.9 377.6 250.3 88.16–1,345 50
VEGF (pg/mL)
<1 wk 62.05 35.04 38.51 85.59 46.18 30.55–132.8 11
1–2 wks 88.83 70.74 41.31 136.4 59.36 20.5–206.3 11
12–16 wks 52.15 35.77 29.42 74.87 41.44 6.24–115.2 12
20–24 wks 44.56 43.2 17.11 72.01 33.78 0–152.7 12
52 wks 33.81 12.87 23.05 44.57 31.34 19.4–58.61 8
5–15yrs 55.61 132.5 17.96 93.27 0 0–707.9 50
IL-18 (pg/mL)
<1 wk 83.52 38.12 56.25 110.8 93.16 0–122.6 10
1–2 wks 121.1 61.34 79.91 162.3 103.2 51.19–249.6 11
12–16 wks 64.18 33.75 46.82 81.53 51.19 22.84–130.3 17
20–24 wks 72.78 72.22 36.86 108.7 62.78 0–276.3 18
52 wks 34.27 31.94 7.57 60.97 30.69 0–90.88 8
5–15yrs NA 0