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. 2020 Jul 16;11:1335. doi: 10.3389/fimmu.2020.01335

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Copyright © 2020 Barbu, Dominical, Mendelsohn and Thein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decrease in neutrophil nuclear segmentation is stimulus- and time-dependent and associates with increased H4 citrullination. (A) Purified healthy neutrophils were treated with NETs stimuli for the specified periods of time and percent of neutrophils with 1-lobe nuclei was quantified by using Lobe Count Feature in IDEAS software. (B) Median Fluorescence Intensity of the H4cit3 signal in 1-lobe normal nuclei. A variable number of experiments were conducted for each stimulus. Filled symbols, RPMI control; empty symbols, stimulus. Paired t-test was used to compare the response in untreated and treated neutrophils. *P < 0.05, **P < 0.01, ***P < 0.001.