Table 1.
Involvement of transient receptor potential vanilloid 4 in a wide range of pathophysiological conditions in diabetes and diabetic complications
| Disease | Tissue/cell type | Species | Experiment | Effect | References |
|---|---|---|---|---|---|
| Type 2 diabetes | Pancreatic ‐cells | Murine | In vitro/in vivo | Modulation of insulin secretion; mediated ‐cell apoptosis | Casas 2008 17 , Skrzypski 2013 9 , Billert 2017 41 |
| Obesity | Adipocytes | Rat, murine, human | In vitro/in vivo | Adipogenesis and energy metabolism; adipose Ca2+ homeostasis and inflammation | Ye 2012 10 , Che 2014 29 , Chen 2015 31 , Janoschek 2016 37 , Sanchez 2016 38 , Sun 2017 44 |
| Skeletal muscle | Murine | In vitro/in vivo | Heightened metabolic capacity | Pritschow 2011 22 , Kusudo 2012 25 | |
| MSC, ASC | Murine | In vitro/in vivo | Increased obesity susceptibility | O’Conor 2013 28 | |
| Sebocyte | Human | In vivo | Influences glucose and lipid metabolism | Olah 2014 30 | |
| Blood | Human | Cross‐sectional studies | Increased genetic susceptibility to obesity | Duan 2015 32 , Tabur 2015 34 | |
| Diabetes‐related CVD | MAECs, Smooth muscle cells | Rat, murine | In vitro/in vivo | Vasodilator response | Earley 2009 19 , Mendoza 2010 20 , Ma 2013 27 , Ye 2018 47 |
| Mesenteric arteries | Rat | In vitro/in vivo | Endothelium‐dependent relaxation | Zou 2015 36 , Matsumoto 2017 43 , Bihzad 2017 40 | |
| CAECs | Rat | In vivo | Shear stress‐induced vasodilation | Kohler 2006 15 | |
| Diabetic nephropathy | HCD cells | Human | In vivo | Role in RVD | Hills 2006 14 , Hills 2012 12 |
| Collecting ducts, tubules | Murine | In vitro/in vivo | Control of mechanosensitivity | Berrout 2012 24 , Wu 2007 16 | |
| Diabetic retinopathy | RMECs, RPE | Rat, murine, human, bovine | In vitro/vivo | Water diffusion and BRB breakdown in the retina; endothelial dysfunction; role in RVD | Monaghan 2015 13 , Zhao 2015 35 , Arredondo 2017 39 , Orduna 2019 49 |
| HCECs | Human | In vivo | Role in RVD | Pan 2008 18 , Mergler 2011 21 | |
| RGCs, Müller cells | Murine | In vitro/in vivo | Polymodal sensory transduction; modulation of calcium flux and apoptosis | Ryskamp 2011 23 , Lakk 2017 42 , Lakk 2018 46 | |
| Painful diabetic neuropathy | DRGs, TGs | Rat, murine | In vitro/in vivo | Modulates mechanosensation; mechanical hyperalgesia | Alessandri 2008 11 , Alexander 2013 26 , Hinata 2018 45 |
| DRGs, sciatic nerve, hind paw plantar skin | Murine | In vitro/in vivo | Mechanical allodynia | Dias 2019 48 | |
| SGCs | Murine | In vitro/in vivo | Nociceptors for inflammatory pain | Rajasekhar 2015 33 |
ASC, subcutaneous adipose‐derived stem cells; BRB, blood–retina barrier; CAECs, carotid artery endothelial cells; CVD, cardiovascular disease; DRGs, dorsal root ganglia; HCD, human collecting duct; HCECs, human corneal endothelial cells; MAECs, mesenteric artery endothelial cells; MSC, bone marrow derived stem cells; RGCs, Retinal ganglion cells; RMECs, retinal microvascular endothelial cells; RPE, retinal pigment epithelium; RVD, regulatory volume decrease; SGCs, satellite glial cells; TGs, trigeminal ganglia.