Table 1.
Anamnestic and laboratory measurement data
| Normal CgA (n = 125) | High CgA (n = 28) | P‐value | |
|---|---|---|---|
| Age (years) | 35.37 ± 12.27 | 36.46 ± 9.88 | 0.7486 |
| Duration of diabetes (years) | 12.89 ± 10.01 | 16.07 ± 8.29 | 0.2432 |
| C‐peptide (ng/mL) | 0.41 ± 0.76 | 0.33 ± 1.20 | 0.8554 |
| Islet cell antibody positivity | 62 | 10 | 1.0000 |
| Glutamic acid decarboxylase antibody positivity | 71 | 11 | 1.0000 |
| Chromogranin A (ng/mL) | 49.80 ± 19.58 | 291.73 ± 248.32 | 0.0006 |
| HbA1C (%) | 8.29 ± 1.96 | 9.62 ± 2.02 | 0.0160 |
| HbA1C (mmol/mol) | 67 ± 21.4 | 82 ± 22.1 | 0.0160 |
| Glycemic control of patients | |||
| Well controlled diabetes | 38 (30.4%) | 1 (3.6 %) | 0.0326 |
| Poorly controlled diabetes | 87 (69.6%) | 27 (94.4 %) | |
| White blood cell count (G/L) | 7.41 ± 2.16 | 7.94 ± 2.03 | 0.3828 |
| Red blood cell count (T/L) | 4.97 ± 0.51 | 4.64 ± 0.55 | 0.0356 |
| Hemoglobin (g/L) | 144.70 ± 15.04 | 131.71 ± 19.37 | 0.0160 |
| Hematocrit (L/L) | 0.429 ± 0.043 | 0.398 ± 0.045 | 0.0160 |
| Mean corpuscular volume (fL) | 86.30 ± 3.34 | 85.44 ± 6.76 | 0.7075 |
| Mean corpuscular hemoglobin (pg) | 29.12 ± 1.39 | 28.41 ± 3.00 | 0.3828 |
| Mean corpuscular hemoglobin concentration (g/L) | 337.54 ± 11.80 | 332.19 ± 16.75 | 0.2978 |
| Red blood cell distribution width (%) | 13.01 ± 0.80 | 13.81 ± 1.60 | 0.0620 |
| Platelets (G/L) | 273.74 ± 65.88 | 309.59 ± 69.25 | 0.0682 |
| Creatinine (µmol/L) | 72.71 ± 13.06 | 79.14 ± 26.35 | 0.3828 |
| Estimated glomerular filtration rate (mL/min/1.73 m2) | 103.94 ± 16.98 | 97.99 ± 25.07 | 0.3828 |
| Total cholesterol (mmol/L) | 5.06 ± 0.97 | 5.68 ± 1.70 | 0.2432 |
| High‐density lipoprotein cholesterol (mmol/L) | 1.66 ± 0.51 | 1.65 ± 0.48 | 0.9552 |
| Low‐density lipoprotein cholesterol (mmol/L) | 2.88 ± 0.72 | 3.38 ± 1.51 | 0.2972 |
| Triglyceride (mmol/L) | 1.18 ± 1.00 | 1.49 ± 1.24 | 0.3828 |
| High sensitivity C‐reactive protein (mg/L) | 1.80 ± 2.20 | 2.43 ± 2.27 | 0.3828 |
| Thyroid‐stimulating hormone (mIU/L) | 2.09 ± 2.35 | 1.85 ± 1.87 | 0.7369 |
| Body mass index (kg/m2) | 24.97 ± 4.95 | 24.51 ± 4.84 | 0.7924 |
| Sex (female/male) | 66/59 (52.8%/47.2%) | 16/12 (57.1%/42.9%) | 0.9907 |
| Latent autoimmune diabetes of adults | 29 (23.2%) | 4 (14.3%) | 0.7237 |
| Hypertension | 40 (32%) | 12 (42.9%) | 0.6380 |
| Autoimmune disease | 15 (12%) | 8 (28.6%) | 0.1231 |
| Vitiligo | 4 (3.2%) | 2 (7.1%) | 0.6380 |
| Alopecia areata | 5 (4%) | 0 (0%) | 0.8342 |
| Pernicious anemia | 2 (1.6%) | 4 (14.3%) | 0.1009 |
| Celiac disease | 2 (1.6%) | 1 (3.6%) | 0.7237 |
| Addison’s disease | 1 (0.8%) | 0 (0%) | 1.0000 |
| Sjögren’s syndrome | 0 (0%) | 1 (3.6%) | 0.4697 |
| Psoriasis vulgaris | 1 (0.8%) | 0 (0%) | 1.0000 |
| Thyroid disease | 39 (31.2%) | 10 (35.7%) | 0.8342 |
| Hashimoto’s thyroiditis | 31 (24.8%) | 5 (17.9%) | 0.8342 |
| Hypothyroidism | 7 (5.6%) | 3 (10.7%) | 0.7237 |
| Hyperthyroidism | 1 (0.8%) | 0 (0%) | 1.0000 |
| Thyroid nodules | 0 (0%) | 2 (7.1%) | 0.1231 |
Unit of non‐laboratory data is the number of observations. CgA, chromogranin A; HbA1C , glycated hemoglobin. P‐values of statistically different results between the two cohorts are indicated with bold text.