Table 2.
Age‐ and sex‐adjusted and multivariable‐adjusted mean values of the total brain volume : intracranial volume ratios according to quartiles of each glycemic measure in 2012
| No. participants |
Age‐ and sex‐adjusted mean values (95% CI) of the TBV : ICV ratio (%) |
P‐value |
Multivariable‐adjusted mean values (95% CI) of the TBV : ICV ratio (%)† |
P‐value |
Multivariable‐adjusted mean values (95%CI) of the TBV : ICV ratio (%)‡ |
P‐value | |
|---|---|---|---|---|---|---|---|
| GA (%) | |||||||
| Q1 (10.2–14.5) | 321 | 78.2 (78.0–78.4) | (Reference) | 78.2 (78.0–78.4) | (Reference) | 78.1 (77.9–78.3) | (Reference) |
| Q2 (14.6–15.6) | 326 | 78.1 (77.9–78.3) | 0.88 | 78.1 (77.9–78.3) | 0.90 | 78.0 (77.9–78.3) | 0.96 |
| Q3 (15.7–17.0) | 317 | 78.2 (78.0–78.4) | 0.99 | 78.2 (78.0–78.4) | 0.99 | 78.2 (78.0–78.4) | 0.96 |
| Q4 (17.1–41.2) | 314 | 77.4 (77.2–77.6) | <0.001 | 77.4 (77.2–77.6) | <0.001 | 77.5 (77.3–77.8) | 0.001 |
| P for trend <0.001 | P for trend <0.001 | P for trend = 0.009 | |||||
| HbA1c (%) | |||||||
| Q1 (4.4–5.4) | 285 | 78.0 (77.8–78.2) | (Reference) | 78.0 (77.8–78.2) | (Reference) | 77.9 (77.7–78.1) | (Reference) |
| Q2 (5.5–5.7) | 419 | 78.2 (78.0–78.0) | 0.36 | 78.2 (78.0–78.4) | 0.35 | 78.1 (77.9–78.3) | 0.28 |
| Q3 (5.8–6.0) | 276 | 78.0 (77.8–78.2) | 1.00 | 78.0 (77.7–78.2) | 0.99 | 77.9 (77.7–78.2) | 0.97 |
| Q4 (6.1–13.6) | 298 | 77.6 (77.4–77.8) | 0.06 | 77.6 (77.4–77.8) | 0.04 | 77.8 (77.6–78.1) | 0.99 |
| P for trend = 0.005 | P for trend = 0.04 | P for trend = 0.69 | |||||
| GA : HbA1c ratio | |||||||
| Q1 (1.89–2.55) | 318 | 78.2 (78.0–78.4) | (Reference) | 78.2 (78.0–78.4) | (Reference) | 78.1 (77.9–78.3) | (Reference) |
| Q2 (2.55–2.72) | 320 | 78.3 (78.1–78.5) | 0.73 | 78.3 (78.1–78.5) | 0.77 | 78.3 (78.1–78.5) | 0.67 |
| Q3 (2.72–2.93) | 321 | 78.0 (77.8–78.2) | 0.46 | 78.0 (77.8–78.2) | 0.39 | 78.0 (77.8–78.2) | 0.57 |
| Q4 (2.93–4.45) | 319 | 77.4 (77.2–77.6) | <0.001 | 77.4 (77.4–77.6) | <0.001 | 77.5 (77.3–77.7) | <0.001 |
| P for trend <0.001 | P for trend <0.001 | P for trend <0.001 | |||||
CI, confidence interval; GA, glycated albumin; GA : HbA1c ratio, glycated albumin : hemoglobin A1c ratio; HbA1c, hemoglobin A1c; ICV, intracranial volume; TBV, total brain volume.
The values were adjusted for age, sex, low education, systolic blood pressure, use of antihypertensive medication, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise.
The values were adjusted for age, sex, low education, systolic blood pressure, use of antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise.