Figure 1.

Dendritic cell subsets. Dendritic cells (DCs) are derived from a common myeloid precursor, from which two precursors can be developed. The first precursor corresponds to the pre-conventional DCs and in murine models they can become conventional DCs (cDCs) type 1 and 2, and within these cells there are different subtypes of DCs. In the cDC1 found two subtypes of cells can be found: CD8⁺ DCs which has the markers CD8⁺, XCR1⁺, CLEC9A⁺, CD205⁺, and CD207⁺, and CD103⁺ DCs that has the markers CD103⁺, CD11c⁺, CD80⁺, CD86⁺, and CD11b⁺. The functional homolog of these cells in human are the CD141^hi DCs, and their markers correspond to CD141^hi, CD45⁺, CD11c^lo, XCR1⁺, and CLEC9A⁺. In the cDC2 subsets are comprised the CD11b⁺ DCs which has the markers CD11b⁺, CD172a^hi, XCR1^lo/−, CD4⁺, and CD11c⁺. The functional homolog of these cells in human are the CD1c⁺ DCs, and their markers are CD1c⁺, CD11c⁺, CD172a⁺, XCR1⁻, and FcεRI⁺. The second precursor corresponds to the pre-plasmacytoid DCs that can become plasmacytoid DCs (pDCs), and in murine models its markers correspond to CD11^lo, B220⁺, CD4⁺, Ly6C^hi, and CD38⁺, while in human, their markers correspond to CD11⁻, B220⁺, CD4⁺, CD11a⁺, and CD38^lo.