Table 1.
DCs subsets, their location, and their surface markers.
| DCs subset | Location | Surface markers | Reference | |||
|---|---|---|---|---|---|---|
| cDCs | Mouse cDC1 (CD8α+) | Lymphoid organs | MHC-II+ Ly6C− B220− CD4− |
CD8α+ CD11blo CD11chi CD24hi |
CD205+ (DEC-205+) CD207+ (Langerin+) CLEC9A+ XCR1+ |
(33–36) |
| Mouse cDC1 (CD103+) | Lymphoid organs and Non-lymphoid organs | MHC-II+ Ly6C− B220− CD8− CD86+ |
CD80+ CD11b+ CD11c+ CD24+ |
CD103+ CD205+ (DEC-205+) CD207+ (Langerin+) XCR1+ |
(37–43) | |
| Human cDC1 (CD141hi) | Lymphoid organs and Non-lymphoid organs | CD11clo CD45+ |
CD141hi (BDCA-3hi) CLEC9A+ |
XCR1+ | (44–46) | |
| Mouse cDC2 (CD11b+) | Lymphoid organs and Non-lymphoid organs | MHC-II+ F4/80− CD4+ CD11b+ |
CD11c+ CD24+ CD64+ |
CD103− CD172ahi (SIRPαhi) XCR1lo/− |
(47, 48) | |
| Human cDC2 (CD1c+) | Lymphoid organs | MHC-II+ CD1alo/+ CD1c+ (BDCA-1+) CD11c+ |
CD14− CD16− CD172a+ (SIRPα+) |
XCR1− FcεRI+ CD207− (Langerin−) |
(47, 49–53) | |
| pDCs | Mouse pDCs | Blood, lymph nodes and lymphoid tissues | MHC-IIlo CD4+ CD11b− B220+ |
CD11clo CD25lo CD38+ CD40− |
CD43+ CD62Lmid Ly6Chi |
(54–56) |
| Human pDCs | Blood and bone marrow | MHC-IIlo B220+ CD1a− CD4+ CD11a+ CD11c− CD13− |
CD14− CD16− CD18+ CD33− CD38lo CD40lo CD44+ |
CD54+ CD62L+ CD123+ (IL-3Rα+) CD127− (IL-7Rα−) CD303+ (BDCA-2+) CD304+ (BDCA-4) |
(57–60) | |